Survivin : a target from brain cancer to neurodegenerative disease

Baratchi, Sara, Kanwar, Rupinder K. and Kanwar, Jagat R. 2010, Survivin : a target from brain cancer to neurodegenerative disease, Critical reviews in biochemistry and molecular biology, vol. 45, no. 6, pp. 535-554, doi: 10.3109/10409238.2010.516740.

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Title Survivin : a target from brain cancer to neurodegenerative disease
Author(s) Baratchi, Sara
Kanwar, Rupinder K.
Kanwar, Jagat R.ORCID iD for Kanwar, Jagat R.
Journal name Critical reviews in biochemistry and molecular biology
Volume number 45
Issue number 6
Start page 535
End page 554
Total pages 20
Publisher Informa Healthcare
Place of publication London, England
Publication date 2010-12
ISSN 1040-9238
Keyword(s) apoptosis
apoptosis inhibitor protein
neurodegenerative disease
Summary Apoptosis is an important contributing factor during neuronal death in a variety of neurodegenerative disorders, including multiple sclerosis, Parkinson's disease and sciatic nerve injury. Whereas several clinical and preclinical studies have focused on the neuroprotective effects of caspase inhibitors, their clinical benefits are still unclear. Here, we discuss novel alternative strategies to protect neuronal cells from apoptotic death using members of the inhibitors of apoptosis (IAP) family. We specifically review the different roles of survivin, which is an important member of the IAP family that serves a dual role in the inhibition of apoptosis as well as a vital role in mitosis and cell division. Due to the various roles of survivin during cell division and apoptosis, targeting this protein illustrates a new therapeutic window for the treatment of neurodegenerative diseases.
Language eng
DOI 10.3109/10409238.2010.516740
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2010
Copyright notice ©2010, Informa Healthcare USA, Inc.
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