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CoQ10 conveys protection from oxidative stress in plasma but not skeletal muscle

Papazzo, Annateresa, Lexis, Louise and Lewandowski, Paul 2010, CoQ10 conveys protection from oxidative stress in plasma but not skeletal muscle, Nutrition and Dietary Supplements, vol. 2, pp. 51-58.

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Title CoQ10 conveys protection from oxidative stress in plasma but not skeletal muscle
Author(s) Papazzo, Annateresa
Lexis, Louise
Lewandowski, Paul
Journal name Nutrition and Dietary Supplements
Volume number 2
Start page 51
End page 58
Publisher Dove Medical Press Ltd
Place of publication Auckland, N.Z.
Publication date 2010-07
ISSN 1179-1489
Keyword(s) coenzyme Q10
aging
skeletal muscle
oxidative damage
gene expression
Summary Coenzyme Q10 (CoQ10) is commonly consumed as an antiaging supplement at doses of 30–210 mg/day. The aim of the study was to determine if CoQ10 alters markers of antioxidant status, oxidative damage, and gene expression in aging skeletal muscle. Female guinea pigs aged 26 months were supplemented for 6 weeks with CoQ10 at a human equivalent dose of 10 mg/kg/day. Body weight, plasma CoQ10 concentration, and WBC DNA abasic sites were measured at weeks 0, 2, 4, and 6 of the supplementation period. At the end of supplementation, concentrations of skeletal muscle CoQ10, glutathione, malondialdehyde, protein carbonyls, DNA abasic sites, activities of catalase and glutathione peroxidase, and the gene expression of cyctochrome c oxidase subunits were measured. Dietary supplementation with CoQ10 elevated plasma CoQ10 levels (pre 73 ± 3 nmol/L, post 581 ± 15 nmol/L, P < 0.05) and decreased abasic sites in WBC DNA (pre 16.8 ± 0.5 Ap/100000 bp, post 9.7 ± 0.4 Ap/100000 bp, P < 0.05). In contrast, all of the measures made in skeletal muscle were not different between groups (P > 0.05). These results indicate that dietary supplementation with CoQ10 at a dose of 10 mg/kg/day may be capable of increasing antioxidant protection and reducing oxidative damage in the plasma, but may have no effect in skeletal muscle.
Language eng
Field of Research 111103 Nutritional Physiology
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, Papazzo et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30031497

Document type: Journal Article
Collections: School of Medicine
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