A novel nanoplatform for oral delivery of anti-cancer biomacromolecules

Mahidhara, Ganesh, Kanwar, Rupinder K. and Kanwar, Jagat R. 2012, A novel nanoplatform for oral delivery of anti-cancer biomacromolecules, International journal of nanotechnology, vol. 9, no. 10/11/12, pp. 942-960.

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Title A novel nanoplatform for oral delivery of anti-cancer biomacromolecules
Author(s) Mahidhara, Ganesh
Kanwar, Rupinder K.
Kanwar, Jagat R.
Journal name International journal of nanotechnology
Volume number 9
Issue number 10/11/12
Start page 942
End page 960
Total pages 19
Publisher Inderscience Publishers
Place of publication Olney, England
Publication date 2012
ISSN 1475-7435
1741-8151
Keyword(s) nano carriers
oral drug delivery
anti┬Ěcancer proteins
chitosan
alginate
ceramic nano cores
lactoferrin
endocytosis
transcytosis
Summary Oral administration of bio–macromolecules is an uphill task and the challenges from varying pH and enzymatic activity are difficult to overcome. In this regard, nanotechnology promises the new hope and offers advantages such as controlled release, target specific delivery, combinatorial therapy and many more. In this study, we demonstrate the formulation of a novel alginate enclosed, chitosan coated ceramic, anti cancer nano carrier (ACSC NC). These NC were loaded with multi functional anti cancer bovine lactoferrin (Lf), a natural milk based protein, for improvement of intestinal absorption, in order to develop a novel platform to carry anti cancer protein and/or peptides for oral therapy. Here we demonstrate the size, morphology, internalisation and release profiles of the nanoparticles (NC) under varying pH as perceived in human digestive system. We further determine the uptake of these particles by colon cancer cell lines by measuring the endocytosis and transcytosis of the NC. These NC can be used for future targeted protein/peptide or nucleic acid based drug delivery to treat difficult diseases including cancer.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30031503

Document type: Journal Article
Collection: Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin)
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