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Receptor mediated tumor targeting : an emerging approach for cancer therapy

Mohanty, Chandana, Das, Manasi, Kanwar, Jagat R. and Sahoo, Sanjeeb K. 2011, Receptor mediated tumor targeting : an emerging approach for cancer therapy, Current drug delivery, vol. 8, no. 1, pp. 45-58.

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Title Receptor mediated tumor targeting : an emerging approach for cancer therapy
Author(s) Mohanty, Chandana
Das, Manasi
Kanwar, Jagat R.
Sahoo, Sanjeeb K.
Journal name Current drug delivery
Volume number 8
Issue number 1
Start page 45
End page 58
Publisher Bentham Science Publishers
Place of publication Bussum, Netherlands
Publication date 2011-01-01
ISSN 1567-2018
1875-5704
Keyword(s) receptor
ligand
nanocarrier
tumor targeting
Summary Receptor-mediated tumor targeting has received major attention in the field of cancer drug delivery in the past few years. Receptors, as molecular target has opened new opportunities for cellular or intracellular targeting of drug loaded delivery systems conjugated with targeting moieties i.e. ligand. This receptor mediated targeting of cancer drug through nano carrier sys¬tems to cancerous tissue offer protection and improves the pharmacokinetics of various drugs and help to overcome the systemic toxicity and adverse effects that result from the non-selective nature of most current cancer therapeutic agents. The article reviews the scope of receptor mediated targeting of anticancer drug loaded in various nanocarriers and also summarize recent perspective and challenges in the field of nanocarrier-aided drug delivery and drug targeting for cancer therapy.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30031508

Document type: Journal Article
Collection: Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin)
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Created: Thu, 09 Dec 2010, 09:26:14 EST by Kislay Roy