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Lactoferrin and cancer in different cancer models Gibbons, Jessica A., Kanwar, Rupinder K. and Kanwar, Jagat R. 2011, Lactoferrin and cancer in different cancer models, Frontiers in Bioscience, vol. S3, no. (Scholar Edition), pp. 1080-1088. Title Lactoferrin and cancer in different cancer models Author(s) Gibbons, Jessica A. Kanwar, Rupinder K. Kanwar, Jagat R. Journal name Frontiers in Bioscience Volume number S3 Issue number (Scholar Edition) Start page 1080 End page 1088 Publisher Frontiers in Bioscience Place of publication Albertson, N.Y. Publication date 2011-06-01 ISSN 1945-0516 1945-0524 Summary Lactoferrin (Lf) is a multifunctional protein and an essential element of innate immunity. Cancer is a major killer in today's world accounting for around 13% of all deaths according to the World Health Organisation (W.H.O.). The five most common forms of cancer include lung, colorectal, stomach, liver and breast cancer. Lactoferrin is a natural forming iron-binding glycoprotein with antibacterial, antioxidant and anti-carcinogenic effects. It is produced in exocrine glands and is secreted in many external fluids as a first line of defence. Lactoferrin also has the capacity to induce apoptosis and inhibit proliferation in cancer cells as well as restore white and red blood cell levels after chemotherapy. This review focuses on the therapeutic effect bovine sourced lactoferrin has on various forms of cancer in various models. It also focuses on the benefits of 3D in vitro cell culture. 3D cell culture has vast advantages over 2D models including demonstration of realistic therapeutic results and heightened resistance that 2D models fail to display. Language eng Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal HERDC collection year 2011 Copyright notice ©2011, Frontiers in Bioscience Persistent URL http://hdl.handle.net/10536/DRO/DU:30031516 Document type: Journal Article Collection: Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin) Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Thu, 09 Dec 2010, 09:50:44 EST Fri, 10 Dec 2010, 12:13:45 EST Tue, 14 Dec 2010, 11:47:55 EST Tue, 14 Dec 2010, 13:40:41 EST Tue, 14 Dec 2010, 13:43:41 EST Wed, 12 Jan 2011, 11:20:30 EST Wed, 12 Jan 2011, 14:30:42 EST Thu, 13 Jan 2011, 17:35:07 EST Mon, 17 Jan 2011, 11:44:36 EST Mon, 17 Jan 2011, 11:45:41 EST Tue, 08 Mar 2011, 14:24:06 EST Wed, 25 May 2011, 09:19:17 EST Wed, 25 May 2011, 09:25:42 EST Wed, 25 May 2011, 10:22:02 EST Fri, 08 Jul 2011, 14:47:18 EST Thu, 29 Sep 2011, 17:24:50 EST Mon, 03 Oct 2011, 13:54:00 EST Mon, 03 Oct 2011, 13:54:49 EST Mon, 03 Oct 2011, 13:58:07 EST Wed, 12 Oct 2011, 15:10:59 EST Thu, 13 Oct 2011, 07:50:02 EST Thu, 13 Oct 2011, 07:51:05 EST Thu, 13 Oct 2011, 07:53:14 EST Mon, 09 Dec 2013, 10:01:14 EST Filtered Full Access Statistics: 156 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Thu, 09 Dec 2010, 09:50:40 EST by Kislay Roy

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