Lactoferrin and cancer in different cancer models

Gibbons, Jessica A., Kanwar, Rupinder K. and Kanwar, Jagat R. 2011, Lactoferrin and cancer in different cancer models, Frontiers in Bioscience, vol. S3, no. (Scholar Edition), pp. 1080-1088, doi: 10.2741/212.

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Title Lactoferrin and cancer in different cancer models
Author(s) Gibbons, Jessica A.
Kanwar, Rupinder K.
Kanwar, Jagat R.ORCID iD for Kanwar, Jagat R.
Journal name Frontiers in Bioscience
Volume number S3
Issue number (Scholar Edition)
Start page 1080
End page 1088
Total pages 9
Publisher Frontiers in Bioscience
Place of publication Albertson, N.Y.
Publication date 2011-06-01
ISSN 1945-0516
Summary Lactoferrin (Lf) is a multifunctional protein and an essential element of innate immunity. Cancer is a major killer in today's world accounting for around 13% of all deaths according to the World Health Organisation (W.H.O.). The five most common forms of cancer include lung, colorectal, stomach, liver and breast cancer. Lactoferrin is a natural forming iron-binding glycoprotein with antibacterial, antioxidant and anti-carcinogenic effects. It is produced in exocrine glands and is secreted in many external fluids as a first line of defence. Lactoferrin also has the capacity to induce apoptosis and inhibit proliferation in cancer cells as well as restore white and red blood cell levels after chemotherapy. This review focuses on the therapeutic effect bovine sourced lactoferrin has on various forms of cancer in various models. It also focuses on the benefits of 3D in vitro cell culture. 3D cell culture has vast advantages over 2D models including demonstration of realistic therapeutic results and heightened resistance that 2D models fail to display.
Language eng
DOI 10.2741/212
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2011
Copyright notice ©2011, Frontiers in Bioscience
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