Comparison of different maximum safe levels in fortified foods and supplements using a probabilistic risk assessment approach

Dufour, Ariane, Wetzler, Sandrine, Touvier, Mathilde, Lioret, Sandrine, Gioda, Jennifer, Lafay, Lionel, Dubuisson, Carine, Calamassi-Tran, Gloria, Kalonji, Esther, Margaritis, Irene and Volatier, Jean-Luc 2010, Comparison of different maximum safe levels in fortified foods and supplements using a probabilistic risk assessment approach, British Journal of Nutrition, vol. 104, no. 12, pp. 1848-1857, doi: 10.1017/S0007114510002862.

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Title Comparison of different maximum safe levels in fortified foods and supplements using a probabilistic risk assessment approach
Author(s) Dufour, Ariane
Wetzler, Sandrine
Touvier, Mathilde
Lioret, Sandrine
Gioda, Jennifer
Lafay, Lionel
Dubuisson, Carine
Calamassi-Tran, Gloria
Kalonji, Esther
Margaritis, Irene
Volatier, Jean-Luc
Journal name British Journal of Nutrition
Volume number 104
Issue number 12
Start page 1848
End page 1857
Publisher Cambridge University Press
Place of publication Cambridge, England
Publication date 2010-12
ISSN 0007-1145
Keyword(s) vitamins
dietary supplements
fortified foods
tolerable upper intake levels
Summary Different European institutions have developed mathematical models to propose maximum safe levels either for fortified foods or for dietary supplements. The objective of the present study was to compare and check the safety of these different maximum safe levels (MSL) by using a probabilistic risk assessment approach. The potential maximum nutritional intakes were estimated by taking into account all sources of intakes (base diet, fortified foods and dietary supplements) and compared with the tolerable upper intake levels for vitamins and minerals. This approach simulated the consequences of both food fortification and supplementation in terms of food safety. Different scenarios were tested. They are the result of the combination of several MSL obtained using the previous models. The study was based on the second French Individual and National Study on Food Consumption performed in 2006–7, matched with the French food nutritional composition database. The analyses were based on a sample of 1918 adults aged 18–79 years. Some MSL in fortified foods and dietary supplements obtained independently were protective enough, although some others could lead to nutritional intakes above the tolerable upper intake levels. The simulation showed that it is crucial to consider the inter-individual variability of fortified food intakes when setting MSL for foods and supplements. The risk assessment approach developed here by integrating the MSL for fortified foods and dietary supplements is useful for ensuring consumer protection. It may be subsequently used to test any other MSL for vitamins and minerals proposed in the future.
Language eng
DOI 10.1017/S0007114510002862
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 920406 Food Safety
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2010, Cambridge University Press
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Created: Mon, 13 Dec 2010, 10:25:09 EST by Penny Andrews

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