Disposition pathways and pharmacokinetics of herbal medicines in humans

He, S. M., Li, C. G., Liu, J. P., Chan, E., Duan, W. and Zhou, S. F. 2010, Disposition pathways and pharmacokinetics of herbal medicines in humans, Current medicinal chemistry, vol. 17, no. 33, pp. 4072-4113.

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Title Disposition pathways and pharmacokinetics of herbal medicines in humans
Author(s) He, S. M.
Li, C. G.
Liu, J. P.
Chan, E.
Duan, W.ORCID iD for Duan, W. orcid.org/0000-0001-5782-9184
Zhou, S. F.
Journal name Current medicinal chemistry
Volume number 17
Issue number 33
Start page 4072
End page 4113
Total pages 42
Publisher Bentham Science Publishers
Place of publication Amsterdam, The Netherlands
Publication date 2010-01-01
ISSN 0929-8673
Summary Pharmacokinetic studies have become an integral part of modern drug development, but these studies are not regulatory needs for herbal remedies. This paper updates our current knowledge on the disposition pathways and pharmacokinetic properties of commonly used herbal medicines in humans. To retrieve relevant data, the authors have searched through computer-based literatures by full text search in Medline (via Pubmed), ScienceDirect, Current Contents Connect (ISI), Cochrance Library, CINAHL (EBSCO), CrossRef Search and Embase (all from inception to May 2010). Many herbal compounds undergo Phase I and/or Phase II metabolism in vivo, with cytochrome P450s (CYPs) and uridine diphosphate glucuronosyltransferases (UGTs) playing a major role. Some herbal ingredients are substrates of P-glycoprotein (P-gp) which is highly expressed in the intestine, liver, brain and kidney. As such, the activities of these drug metabolizing enzymes and drug transporters are determining factors for the in vivo bioavailability, disposition and distribution of herbal remedies. There are increasing pharmacokinetic studies of herbal remedies, but these studies are mainly focused on a small number of herbal remedies including St John's wort, milk thistle, sculcap, curcumin, echinacea, ginseng, ginkgo, and ginger. The pharmacokinetic data of a small number of purified herbal ingredients, including anthocyanins, berberine, catechins, curcumin, lutein and quercetin, are available. For the majority of herbal remedies used in folk medicines, data on their disposition and biological fate in humans are lacking or in paucity. For a herbal medicine, the pharmacological effect is achieved when the bioactive agents or the metabolites reach and sustain proper levels at their sites of action. Both the dose levels and fates of active components in the body govern their target-site concentrations after administration of an herbal remedy. In this regard, a safe and optimal use of herbal medicines requires a full understanding of their pharmacokinetic profiles. To optimize the use of herbal remedies, further clinical studies to explore their biological fate including the disposition pathways and kinetics in the human body are certainly needed.
Language eng
Field of Research 111504 Pharmaceutical Sciences
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Grant ID NHMRC 479505
Copyright notice ©2010, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30032068

Document type: Journal Article
Collection: School of Medicine
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