Reinforcing silk scaffolds with silk particles

Rajkhowa, Rangam, Gil, Eun Seok, Kluge, Jonathan, Numata, Keiji, Wang, Lijing, Wang, Xungai and Kaplan, David L 2010, Reinforcing silk scaffolds with silk particles, Macromolecular bioscience, vol. 10, no. 6, pp. 599-611.

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Title Reinforcing silk scaffolds with silk particles
Author(s) Rajkhowa, Rangam
Gil, Eun Seok
Kluge, Jonathan
Numata, Keiji
Wang, Lijing
Wang, Xungai
Kaplan, David L
Journal name Macromolecular bioscience
Volume number 10
Issue number 6
Start page 599
End page 611
Total pages 13
Publisher Wiley Interscience
Place of publication Weinheim, Germany
Publication date 2010-06-10
ISSN 1616-5187
1616-5195
Keyword(s) biodegradable
composites
particles
scaffolds
silk
Summary Silk fibroin is a useful protein polymer for biomaterials and tissue engineering. In this work, porogen leached scaffolds prepared from aqueous and HFIP silk solutions were reinforced through the addition of silk particles. This led to about 40 times increase in the specific compressive modulus and the yield strength of HFIP-based scaffolds. This increase in mechanical properties resulted from the high interfacial cohesion between the silk matrix and the reinforcing silk particles, due to partial solubility of the silk particles in HFIP. The porosity of scaffolds was reduced from ≈90% (control) to ≈75% for the HFIP systems containing 200% particle reinforcement, while maintaining pore interconnectivity. The presence of the particles slowed the enzymatic degradation of silk scaffolds.

Language eng
Field of Research 091012 Textile Technology
Socio Economic Objective 860403 Natural Fibres, Yarns and Fabrics
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
HERDC collection year 2010
Copyright notice ©2010, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Persistent URL http://hdl.handle.net/10536/DRO/DU:30032204

Document type: Journal Article
Collection: Centre for Material and Fibre Innovation
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