Effect of an arginine-containing nutritional supplement on pressure ulcer healing in community spinal patients

Brewer, S., Desneves, K., Pearce, L., Mills, K., Dunn, L., Brown, D. and Crowe, T. 2010, Effect of an arginine-containing nutritional supplement on pressure ulcer healing in community spinal patients, Journal of wound care, vol. 19, no. 7, pp. 311-316.

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Title Effect of an arginine-containing nutritional supplement on pressure ulcer healing in community spinal patients
Author(s) Brewer, S.
Desneves, K.
Pearce, L.
Mills, K.
Dunn, L.
Brown, D.
Crowe, T.
Journal name Journal of wound care
Volume number 19
Issue number 7
Start page 311
End page 316
Total pages 6
Publisher Mark Allen Publishing
Place of publication London, England
Publication date 2010-07
ISSN 0969-0700
Keyword(s) arginine
pressure ulcer
spinal cord injuries
wound healing
Summary Objective: To determine whether or not the use of an arginine-containing nutritional supplement could result in signifi cantly shorter pressure ulcer (PU) healing times in people with spinal cord injuries living in the community, compared with a comparative historical control group. Method: Eighteen spinal-cord-injured patients (all part of a hospital spinal outreach service) received 9g of a commercial powdered arginine supplement per day until full PU healing occurred. Healing rates were compared against 17 historical control patients (as assessed by medical history audit). 
Results: Baseline characteristics (age, gender, injury level and time) were similar between groups. Mean ulcer healing times were 10.5 ± 1.3 weeks versus 21 ± 3.7 weeks (p<0.05) in the intervention and control groups respectively. Comparison of healing rates in the intervention group against expected healing rates derived from the medical literature showed that intervention patients had a signifi cantly shorter mean healing time (category 2 PU: 5.5±1.3 weeks versus 13.4 weeks; category 3 PU: 12.5 ± 1.9 weeks versus 18.2 weeks; category 4 PU: 14.4 ± 4.8 weeks versus 22.1 weeks). A diagnosis of diabetes did not significantly alter healing rates in either group. Conclusion: Results from this observational study show a promising benefit of arginine supplementation on PU healing for individuals with spinal cord injury living in the community.
Language eng
Field of Research 111101 Clinical and Sports Nutrition
Socio Economic Objective 920117 Skin and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, Mark Allen Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30032571

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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