The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy

Foletta, Victoria C., White, Lloyd J., Larsen, Amy E., Léger, Bertrand and Russell, Aaron P. 2011, The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy, Pfluegers Archiv: European journal of physiology, vol. 461, no. 3, pp. 325-335, doi: 10.1007/s00424-010-0919-9.

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Title The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy
Author(s) Foletta, Victoria C.ORCID iD for Foletta, Victoria C.
White, Lloyd J.
Larsen, Amy E.
Léger, Bertrand
Russell, Aaron P.ORCID iD for Russell, Aaron P.
Journal name Pfluegers Archiv: European journal of physiology
Volume number 461
Issue number 3
Start page 325
End page 335
Total pages 11
Publisher Springer
Place of publication Heidelberg, Germany
Publication date 2011-03
ISSN 0031-6768
Keyword(s) Skeletal muscle
Muscle damage
Myosin heavy chain
Myogenic response
Summary Skeletal muscle atrophy occurs in many chronic diseases and disuse conditions. Its severity reduces patient recovery, independence and quality of life. The discovery of two muscle-specific E3 ubiquitin ligases, MAFbx/ atrogin-1 and Muscle RING Finger-1 (MuRF1), promoted an expectation of these molecules as targets for therapeutic development. While numerous studies have determined the conditions in which MAFbx/atrogin-1 and MuRF1 mRNA levels are regulated, few studies have investigated their functional role in skeletal muscle. Recently, studies identifying new target substrates for MAFbx/atrogin-1 and
MuRF1, outside of their response to the initiation of muscle atrophy, suggest that there is more to these proteins than
previously appreciated. This review will highlight our present knowledge of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy, the impact of potential therapeutics and their known regulators and substrates. Finally, we will comment on new approaches that may expand our knowledge of these two molecules in their control of skeletal muscle function.
Language eng
DOI 10.1007/s00424-010-0919-9
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
060699 Physiology not elsewhere classified
111699 Medical Physiology not elsewhere classified
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
Grant ID NHMRC 479536
Copyright notice ©2011, Springer-Verlag
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Document type: Journal Article
Collection: Centre for Physical Activity and Nutrition Research
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Created: Sat, 12 Feb 2011, 08:29:51 EST by Aaron Russell

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