The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy

Foletta, Victoria C., White, Lloyd J., Larsen, Amy E., Léger, Bertrand and Russell, Aaron P. 2011, The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy, Pfluegers Archiv: European journal of physiology, vol. 461, no. 3, pp. 325-335.

Attached Files
Name Description MIMEType Size Downloads

Title The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy
Author(s) Foletta, Victoria C.
White, Lloyd J.
Larsen, Amy E.
Léger, Bertrand
Russell, Aaron P.
Journal name Pfluegers Archiv: European journal of physiology
Volume number 461
Issue number 3
Start page 325
End page 335
Total pages 11
Publisher Springer
Place of publication Heidelberg, Germany
Publication date 2011-03
ISSN 0031-6768
1432-2013
Keyword(s) Skeletal muscle
Regeneration
Muscle damage
Myosin heavy chain
Myogenic response
Summary Skeletal muscle atrophy occurs in many chronic diseases and disuse conditions. Its severity reduces patient recovery, independence and quality of life. The discovery of two muscle-specific E3 ubiquitin ligases, MAFbx/ atrogin-1 and Muscle RING Finger-1 (MuRF1), promoted an expectation of these molecules as targets for therapeutic development. While numerous studies have determined the conditions in which MAFbx/atrogin-1 and MuRF1 mRNA levels are regulated, few studies have investigated their functional role in skeletal muscle. Recently, studies identifying new target substrates for MAFbx/atrogin-1 and
MuRF1, outside of their response to the initiation of muscle atrophy, suggest that there is more to these proteins than
previously appreciated. This review will highlight our present knowledge of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy, the impact of potential therapeutics and their known regulators and substrates. Finally, we will comment on new approaches that may expand our knowledge of these two molecules in their control of skeletal muscle function.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
060699 Physiology not elsewhere classified
111699 Medical Physiology not elsewhere classified
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, Springer-Verlag
Persistent URL http://hdl.handle.net/10536/DRO/DU:30032658

Document type: Journal Article
Collection: Centre for Physical Activity and Nutrition Research
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 58 times in TR Web of Science
Scopus Citation Count Cited 63 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 314 Abstract Views, 4 File Downloads  -  Detailed Statistics
Created: Sat, 12 Feb 2011, 08:29:51 EST by Aaron Russell

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.