Domino Heck-Aza-Michael reactions : efficient access to 1-substituted tetrahydro-β-carbolines

Priebbenow, Daniel L., Henderson, Luke C., Pfeffer, Frederick M. and Stewart, Scott G. 2010, Domino Heck-Aza-Michael reactions : efficient access to 1-substituted tetrahydro-β-carbolines, Journal of organic chemistry, vol. 75, no. 5, pp. 1787-1790.

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Title Domino Heck-Aza-Michael reactions : efficient access to 1-substituted tetrahydro-β-carbolines
Formatted title Domino Heck-Aza-Michael reactions : efficient access to 1-substituted tetrahydro-β-carbolines
Author(s) Priebbenow, Daniel L.
Henderson, Luke C.
Pfeffer, Frederick M.
Stewart, Scott G.
Journal name Journal of organic chemistry
Volume number 75
Issue number 5
Start page 1787
End page 1790
Total pages 14
Publisher American Chemical Society
Place of publication Washington, D.C.
Publication date 2010-03-05
ISSN 0022-3263
1520-6904
Summary A simple and efficient palladium-catalyzed domino reaction for the synthesis of a series of C1-substituted tetrahydro-β-carbolines is described. This domino process involves a Heck reaction at the indole 2-position of a halogenated tryptamine precursor, followed by intramolecular aza-Michael addition.
Language eng
Field of Research 030503 Organic Chemical Synthesis
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2010
Copyright notice ©2010, American Chemical Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30032923

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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