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Formulation optimization for high drug loading colonic drug delivery carrier

Wang, Yichao, Li, Puwang, Kong, Lingxue, Peng, Zheng and Luo, Yongyue 2010, Formulation optimization for high drug loading colonic drug delivery carrier, in BMEI 2010 : Proceedings of the 3rd International Conference on Biomedical Engineering and Informatics, IEEE, Piscataway, N.J., pp. 1686-1689.

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Title Formulation optimization for high drug loading colonic drug delivery carrier
Author(s) Wang, Yichao
Li, Puwang
Kong, Lingxue
Peng, Zheng
Luo, Yongyue
Conference name Biomedical Engineering and Informatics International Conference (3rd : 2010 : Yantai, China)
Conference location Yantai, China
Conference dates 16-18 Oct. 2010
Title of proceedings BMEI 2010 : Proceedings of the 3rd International Conference on Biomedical Engineering and Informatics
Editor(s) Yu, Weichuan
Zhang, Ming
Wang, Lipo
Song, Yibin
Publication date 2010
Conference series Biomedical Engineering and Informatics International Conference
Start page 1686
End page 1689
Total pages 4
Publisher IEEE
Place of publication Piscataway, N.J.
Keyword(s) 5-Fluorouracel (5-FU)
PLGA
optimization
nanoparticles
Summary High drug loading (DL) carrier is an effective way to cure the cancerous cells. High drug loading is also one of the key issues in the drug delivery research, especially the colonic drug delivery system by oral administration. The times of drug intake could be remarkably reduced if high drug loading carriers are administered. At the same time, the related formulation materials could be effectively utilized. One major obstacle with the preparation of this system is the difficulty to encapsulate the hydrophilic drug into hydrophobic encapsulation polymer. A design of high drug loading delivery system with biodegradable, biocompatible materials and optimization of the fabrication process is a potential solution to solve the problem. So in this research, 5-Fluorouracil (5-FU) loaded Poly (lactide-co-glycolide) (PLGA) nanoparticles were prepared by double emulsion and solvent evaporation method. Several fabrication parameters including theoretical drug loading, volume ratio of outer water phase to the first emulsion, pH value of outer aqueous phase and emulsifier PVA concentration were optimized to get a high drug loading nanoparticles. The result shows that with the increase of theoretical drug loading, the actual drug loading increased gradually. When adjusted the pH value of outer aqueous phase to the isoelectric point (8.02) of 5-Fluorouracil, the drug loading exhibited a higher one compared to other pH value solution. Relative higher volume ratio of outer water phase to the first emulsion was also beneficial for the enhancement of drug loading. But the nanoparticles size increased simultaneously due to the lower shearing force. When increased the PVA concentration, the drug loading showed an increase first and following a drop.
Notes This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.
ISBN 9781424464982
Language eng
Field of Research 090301 Biomaterials
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category E1 Full written paper - refereed
HERDC collection year 2010
Copyright notice ©2010, IEEE
Persistent URL http://hdl.handle.net/10536/DRO/DU:30032974

Document type: Conference Paper
Collections: Centre for Material and Fibre Innovation
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