Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet

Guimarães, Lísia Rejane, Jacka, Felice N., Gama, Clarissa Severino, Berk, Michael, Leitão-Azevedo, Carmen Lúcia, Belmonte de Abreu, Martha Guerra, Lobato, Maria Inês, Andreazza, Ana Cristina, Ceresér, Keila Maria, Kapczinski, Flávio and Belmonte-de-Abreu, Paulo 2008, Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet, Progress in neuro-psychopharmacology & biological psychiatry, vol. 32, no. 6, pp. 1595-1598.

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Title Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet
Author(s) Guimarães, Lísia Rejane
Jacka, Felice N.
Gama, Clarissa Severino
Berk, Michael
Leitão-Azevedo, Carmen Lúcia
Belmonte de Abreu, Martha Guerra
Lobato, Maria Inês
Andreazza, Ana Cristina
Ceresér, Keila Maria
Kapczinski, Flávio
Belmonte-de-Abreu, Paulo
Journal name Progress in neuro-psychopharmacology & biological psychiatry
Volume number 32
Issue number 6
Start page 1595
End page 1598
Total pages 4
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2008-08-01
ISSN 0278-5846
1878-4216
Keyword(s) BDNF
BMI
hypocaloric diet
neurotrophins
schizophrenia
Summary Dietary factors influence BDNF in animal studies, but there is no comparable data in clinical populations. We examined the effect of a dietary intervention on BDNF serum levels in 67 DSM-IV schizophrenic outpatients (51 males and 16 females). Two groups were assessed in a cross-sectional study: one on a hypocaloric diet (HD) and the other not on a hypocaloric diet. Weight, height and BMI data were collected concurrently with 5-ml blood sampling of each subject. BDNF levels were measured with a sandwich-ELISA. The blood sample was obtained a minimum of one month after the exposure to dietary intervention. Serum BDNF levels were significantly higher in patients on the HD (p = 0.023). Additional research examining the interaction among patterns of nutritional food behavior and underlying physiopathology may result in insights upon which evidence-based decisions regarding dietary interventions can be made in people identified with major psychiatric disorders, such as schizophrenia.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, Elsevier Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033157

Document type: Journal Article
Collection: School of Medicine
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