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Depression and bone mineral density in a community sample of perimenopausal women: Geelong Osteoporosis Study Jacka, Felice N., Pasco, Julie A., Henry, Margaret J., Kotowicz, Mark A., Dodd, Seetal, Nicholson, Geoff C. and Berk, Michael 2005, Depression and bone mineral density in a community sample of perimenopausal women: Geelong Osteoporosis Study, Menopause, vol. 12, no. 1, January-February, pp. 88-91. Attached Files Name Description MIMEType Size Downloads Title Depression and bone mineral density in a community sample of perimenopausal women: Geelong Osteoporosis Study Author(s) Jacka, Felice N. Pasco, Julie A. Henry, Margaret J. Kotowicz, Mark A. Dodd, Seetal Nicholson, Geoff C. Berk, Michael Journal name Menopause Volume number 12 Issue number 1 Season January-February Start page 88 End page 91 Publisher Raven Press (Lippincott Williams & Wilkins) Place of publication New York, N. Y. Publication date 2005-01 ISSN 1072-3714 1530-0374 Keyword(s) depression bone mineral density osteoporosis cortisol Summary Objective: Reduced bone mineral density (BMD) in women with a history of depressive disorders has been shown in some, but not all studies. This study investigated the association between self-reported depression and BMD in an age-stratified community sample of perimenopausal women residing in the South-Eastern region of Australia. Design: Symptoms of depression in the year between July 2000 and July 2001 were ascertained by a self-report questionnaire based on Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria. Women in the perimenopausal group who had undergone a BMD total hip and spine assessment within the 12-month period after the depression assessment were included in the analysis, resulting in a sample of 78 women aged 45 to 60 years. Results: In this sample, 14 women were identified as depressed. There was no difference in age, hormone therapy (HT) use, or unadjusted BMD at the total hip or spine between the depressed and nondepressed women (P = 0.14, 0.89, 0.57, and 0.70, respectively), but the depressed women tended to be heavier [depressed (median weight, interquartile range = 80 kg, 66-94) vs nondepressed (72 kg, 61-80) P = 0.06]. Whereas there was no significant difference in age-, HT-, and weight-adjusted BMD at the spine [depressed (mean ± SE = 1.21 ± 0.05) vs nondepressed (1.28 ± 0.03 g/cm2) P = 0.18], adjusted BMD at the total hip for the depressed women was 7.8% lower than for the nondepressed [depressed (mean ± SE = 0.957 ± 0.038) vs nondepressed (1.038 ± 0.023 g/cm2) P = 0.04]. Conclusions: These results suggest that in perimenopausal women, self-reported depression is associated with lower BMD at the hip. Language eng Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Related work DU:30042980 Copyright notice ©2005, Lippincott Williams & Wilkins Persistent URL http://hdl.handle.net/10536/DRO/DU:30033164 Document type: Journal Article Collection: School of Medicine Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Link to Related Work Dietary selenium intake and major depressive disorder Journal Article (deposited 23-06-2011) Geelong Osteoporosis Study Health Database Data Collection (deposited 06-03-2012) Clinical implications of the cytokine hypothesis of depression: the association between use of statins and aspirin and the risk of major depression Journal Article (deposited 03-03-2011) The distribution and characteristic of depressive and anxiety disorders in Australian women Conference Paper (deposited 23-06-2011) The distribution and characteristics of depressive and anxiety disorders in Australian women Journal Article (deposited 23-06-2011) Leptin in depressed women : cross sectional and longitudinal data from an epidemiologic study Journal Article (deposited 23-06-2011) Depression and bone mineral density in a community sample of perimenopausal women : The Geelong Osteoporosis Study Conference Paper (deposited 22-06-2011) Bone mineral density and depression in premenopausal women Conference Paper (deposited 23-06-2011) Diet quality is associated with the common mental disorders Journal Article (deposited 23-06-2011) SSRI use and bone mineral density in women with affective disorders : Geelong Osteoporosis Study (GOS) Journal Article (deposited 23-06-2011) The association of high sensitivity C-reactive protein levels with major depression : a ten-year longitudinal study. 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