Depression and bone mineral density in a community sample of perimenopausal women: Geelong Osteoporosis Study

Jacka, Felice N., Pasco, Julie A., Henry, Margaret J., Kotowicz, Mark A., Dodd, Seetal, Nicholson, Geoff C. and Berk, Michael 2005, Depression and bone mineral density in a community sample of perimenopausal women: Geelong Osteoporosis Study, Menopause, vol. 12, no. 1, January-February, pp. 88-91.

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Title Depression and bone mineral density in a community sample of perimenopausal women: Geelong Osteoporosis Study
Author(s) Jacka, Felice N.
Pasco, Julie A.
Henry, Margaret J.
Kotowicz, Mark A.
Dodd, Seetal
Nicholson, Geoff C.
Berk, Michael
Journal name Menopause
Volume number 12
Issue number 1
Season January-February
Start page 88
End page 91
Publisher Raven Press (Lippincott Williams & Wilkins)
Place of publication New York, N. Y.
Publication date 2005-01
ISSN 1072-3714
1530-0374
Keyword(s) depression
bone mineral density
osteoporosis
cortisol
Summary Objective: Reduced bone mineral density (BMD) in women with a history of depressive disorders has been shown in some, but not all studies. This study investigated the association between self-reported depression and BMD in an age-stratified community sample of perimenopausal women residing in the South-Eastern region of Australia.

Design: Symptoms of depression in the year between July 2000 and July 2001 were ascertained by a self-report questionnaire based on Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria. Women in the perimenopausal group who had undergone a BMD total hip and spine assessment within the 12-month period after the depression assessment were included in the analysis, resulting in a sample of 78 women aged 45 to 60 years.

Results: In this sample, 14 women were identified as depressed. There was no difference in age, hormone therapy (HT) use, or unadjusted BMD at the total hip or spine between the depressed and nondepressed women (P = 0.14, 0.89, 0.57, and 0.70, respectively), but the depressed women tended to be heavier [depressed (median weight, interquartile range = 80 kg, 66-94) vs nondepressed (72 kg, 61-80) P = 0.06]. Whereas there was no significant difference in age-, HT-, and weight-adjusted BMD at the spine [depressed (mean ± SE = 1.21 ± 0.05) vs nondepressed (1.28 ± 0.03 g/cm2) P = 0.18], adjusted BMD at the total hip for the depressed women was 7.8% lower than for the nondepressed [depressed (mean ± SE = 0.957 ± 0.038) vs nondepressed (1.038 ± 0.023 g/cm2) P = 0.04].

Conclusions: These results suggest that in perimenopausal women, self-reported depression is associated with lower BMD at the hip.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Related work DU:30042980
Copyright notice ©2005, Lippincott Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033164

Document type: Journal Article
Collection: School of Medicine
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