Depression and bone mineral density in a community sample of men : Geelong Osteoporosis Study

Jacka, F. N., Pasco, J. A., Henry, M. J., Korn, S., Williams, L. J., Kotowicz, M. A., Nicholson, G. C. and Berk, M. 2007, Depression and bone mineral density in a community sample of men : Geelong Osteoporosis Study, Journal of men's health & gender, vol. 4, no. 3, pp. 292-297.

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Title Depression and bone mineral density in a community sample of men : Geelong Osteoporosis Study
Author(s) Jacka, F. N.
Pasco, J. A.
Henry, M. J.
Korn, S.
Williams, L. J.
Kotowicz, M. A.
Nicholson, G. C.
Berk, M.
Journal name Journal of men's health & gender
Volume number 4
Issue number 3
Start page 292
End page 297
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2007-09
ISSN 1571-8913
Keyword(s) depression
esteoporosis
bone density
men
fracture
Summary Background : Previous research in psychiatric and community samples has demonstrated reduced bone mineral density (BMD) in individuals with both clinical depression and depressive symptoms, although the findings are equivocal. This study aimed to investigate the association between self-reported depression and BMD in a community sample of men aged 20–96 years enrolled in the Geelong Osteoporosis Study.

Methods : A self-report questionnaire based on DSM-IV criteria was used to determine lifetime prevalence rates of depression within the study sample at baseline. Those currently taking oral glucocorticoids, testosterone or bisphosphonates were excluded from the analysis (n = 23) resulting in a sample of 1279 men.

Results : In this sample, 155 men reported a lifetime history of depression (LHX). There were no differences in age, weight, height, calcium intake, smoking rates or unadjusted BMD at the femoral neck between the cases and the controls, whereas unadjusted BMD at the spine was significantly lower in those with a LHX (1.254 ± 0.187 vs 1.293 ± 0.194 g/cm2). BMD adjusted for age, weight, calcium intake and smoking was 3.6% lower at the spine (1.255 ± 0.016 vs 1.295 ± 0.006 g/cm2) and 3.4% lower at the femoral neck (0.973 ± 0.011 vs 1.007 ± 0.004 g/cm2) in those with a LHX compared to controls.

Conclusion : These data are consistent with previous findings of diminished BMD in people with depressive disorders and symptoms and suggest that depression may be a risk factor for reduced BMD in community-dwelling adult men.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Related work DU:30042980
Copyright notice ©2007, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033165

Document type: Journal Article
Collection: School of Medicine
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