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Leptin in depressed women : Cross-sectional and longitudinal data from an epidemiologic study

Pasco, Julie A., Jacka, Felice N., Williams, Lana J., Henry, Margaret J., Nicholson, Geoffrey C., Kotowicz, Mark A. and Berk, Michael 2008, Leptin in depressed women : Cross-sectional and longitudinal data from an epidemiologic study, Journal of affective disorders, vol. 107, no. 1-3, pp. 221-225.

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Title Leptin in depressed women : Cross-sectional and longitudinal data from an epidemiologic study
Author(s) Pasco, Julie A.
Jacka, Felice N.
Williams, Lana J.
Henry, Margaret J.
Nicholson, Geoffrey C.
Kotowicz, Mark A.
Berk, Michael
Journal name Journal of affective disorders
Volume number 107
Issue number 1-3
Start page 221
End page 225
Publisher Elsevier BV
Place of publication Amsterdam, The Netherlands
Publication date 2008-04
ISSN 0165-0327
1573-2517
Keyword(s) leptin
depression
dysthymia
risk factor
body mass index
epidemiology
Summary Background There is conflicting evidence regarding levels of leptin in depression. In this study we aimed to investigate the relationship between serum leptin level and depression in a community sample of women using both cross-sectional and longitudinal data.

Methods From among 510 women aged 20–78 yr, 83 were identified with a lifetime history of major depressive disorder or dysthymia, ascertained using the Structured Clinical Interview for DSM-IV-TR Research Version, Non-patient edition (SCID-I/NP). Serum leptin levels were measured by radioimmunoassay. Medication use and lifestyle were self-reported and body mass index (BMI) determined from measures of height and weight.

Results Using multiple linear regression, serum leptin levels were greater among women with a lifetime history of depression compared to women without any history of depression, independent of BMI. Adjusted geometric mean values of serum leptin were 16.37 (95%CI 14.70–18.23) ng/mL for depressed and 14.46 (95%CI 13.79–15.16) ng/mL for non-depressed women (P = 0.039). The hazard ratio (HR) for a de novo depressive disorder over five years increased 2.56-fold for each standard deviation increase in log-transformed serum leptin among non-smokers and this was not explained by differences in BMI, medications or other lifestyle factors (HR = 2.56, 95%CI 1.52-4.30). No association was observed for smokers.

Limitations There is potential for unrecognised confounding, recall bias and transient changes in body composition.

Conclusion Women with a lifetime history of depression have elevated levels of serum leptin, and elevated serum leptin predicts subsequent development of a depressive disorder.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Related work DU:30042980
Copyright notice ©2007, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033174

Document type: Journal Article
Collection: School of Medicine
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