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Tobacco smoking as a risk factor for major depressive disorder : a population-based study

Pasco, Julie A., Williams, Lana J., Jacka, Felice N., Ng, Felicity, Henry, Margaret J., Nicholson, Geoffrey C., Kotowicz, Mark A. and Berk, Michael 2008, Tobacco smoking as a risk factor for major depressive disorder : a population-based study, British journal of psychiatry, vol. 193, no. 4, pp. 322-326.

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Title Tobacco smoking as a risk factor for major depressive disorder : a population-based study
Author(s) Pasco, Julie A.
Williams, Lana J.
Jacka, Felice N.
Ng, Felicity
Henry, Margaret J.
Nicholson, Geoffrey C.
Kotowicz, Mark A.
Berk, Michael
Journal name British journal of psychiatry
Volume number 193
Issue number 4
Start page 322
End page 326
Publisher Royal College of Psychiatrists
Place of publication London, England
Publication date 2008-10
ISSN 0007-1250
1472-1465
Summary Background : Smoking is disproportionately prevalent among people with psychiatric illness.

Aims : To investigate smoking as a risk factor for major depressive disorder.

Method : A population-based sample of women was studied using case–control and retrospective cohort study designs. Exposure to smoking was self-reported, and major depressive disorder diagnosed using the Structured Clinical Interview for DSM–IV–TR (SCID–I/NP).

Results : Among 165 people with major depressive disorder and 806 controls, smoking was associated with increased odds for major depressive disorder (age-adjusted odds ratio (OR)=1.46, 95% CI 1.03–2.07). Compared with non-smokers, odds for major depressive disorder more than doubled for heavy smokers (>20 cigarettes/day). Among 671 women with no history of major depressive disorder at baseline, 13 of 87 smokers and 38 of 584 non-smokers developed de novo major depressive disorder during a decade of follow-up. Smoking increased major depressive disorder risk by 93% (hazard ratio (HR)=1.93, 95% CI 1.02–3.69); this was not explained by physical activity or alcohol consumption.

Conclusions : Evidence from cross-sectional and longitudinal data suggests that smoking increases the risk of major depressive disorder in women.
Notes This is an author-produced electronic version of an article accepted for publication in the British Journal of Psychiatry. The definitive publisher-authenticated version is available online at http://bjp.rcpsych.org
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Related work DU:30042980
Copyright notice ©2008, Royal College of Psychiatrists
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033177

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.