Lifetime psychiatric disorders and body composition : a population-based study

Williams, Lana J., Pasco, Julie A., Henry, Margaret J., Jacka, Felice N., Dodd, Seetal, Nicholson, Geoffrey C., Kotowicz, Mark A. and Berk, Michael 2009, Lifetime psychiatric disorders and body composition : a population-based study, Journal of affective disorders, vol. 118, no. 1-3, pp. 173-179, doi: 10.1016/j.jad.2009.02.001.

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Title Lifetime psychiatric disorders and body composition : a population-based study
Author(s) Williams, Lana J.ORCID iD for Williams, Lana J.
Pasco, Julie A.ORCID iD for Pasco, Julie A.
Henry, Margaret J.
Jacka, Felice N.ORCID iD for Jacka, Felice N.
Dodd, SeetalORCID iD for Dodd, Seetal
Nicholson, Geoffrey C.
Kotowicz, Mark A.ORCID iD for Kotowicz, Mark A.
Berk, MichaelORCID iD for Berk, Michael
Journal name Journal of affective disorders
Volume number 118
Issue number 1-3
Start page 173
End page 179
Total pages 7
Publisher Elsevier BV
Place of publication Amsterdam, The Netherlands
Publication date 2009-11
ISSN 0165-0327
Keyword(s) depressive disorders
anxiety disorders
body composition
psychiatric epidemiology
imaging techniques
Summary Background This study aimed to investigate the relationship between depressive and anxiety disorders and indices of adiposity, including body fat mass and percent body fat, as measured by dual energy X-ray absorptiometry.

Methods In this observational study of 979 randomly-selected women aged 20–93 years, psychiatric history was ascertained using a structured clinical interview (SCID-I/NP). Total body fat was assessed using dual-energy X-ray absorptiometry and weight, height and waist circumference were measured. Medication use and lifestyle factors were self-reported.

Results Those with a lifetime history of depression had increased fat mass (+ 7.4%) and percent body fat (+ 4.3%), as well as greater mean weight (+ 3.3%), waist circumference (+ 2.9%) and BMI (+ 3.5%) after adjustment for age, anxiety, alcohol consumption, physical activity and past smoking. Furthermore, those meeting criteria for a lifetime history of depression had a 1.7-fold increased odds of being overweight or obese (BMI ≥ 25), a 2.0-fold increased odds of being obese (BMI ≥ 30) and a 1.8-fold increased odds of having a waist circumference ≥ 80 cm. These patterns persisted after further adjustment for psychotropic medication use, smoking status and energy intake. No differences in any measures of adiposity were observed among those with anxiety disorders compared to controls.

There is potential for unrecognised confounding, interpretations are limited to women and a temporal relationship could not be inferred.

Conclusions Depression was associated with greater adiposity. The difference in body fat mass was numerically greater than differences in indirect measures of adiposity, suggesting that the latter may underestimate the extent of adiposity in this population.
Language eng
DOI 10.1016/j.jad.2009.02.001
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Related work DU:30042980
Copyright notice ©2009, Elsevier
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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