Assessing health risk of reclaimed water using human cell culture.

Ackland, M. L., Michalczyk, A. A., Freestone, D. and Stagnitti, F. 2010, Assessing health risk of reclaimed water using human cell culture., Water, vol. 37, no. 8, pp. 39-43.

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Title Assessing health risk of reclaimed water using human cell culture.
Author(s) Ackland, M. L.
Michalczyk, A. A.
Freestone, D.
Stagnitti, F.
Journal name Water
Volume number 37
Issue number 8
Start page 39
End page 43
Total pages 5
Publisher Australian Water Association
Place of publication St Leonards, N.S.W.
Publication date 2010-12
ISSN 0310-0367
Summary For risk analysis of reclaimed water, current animal and toxicity testing may not detect subtle effects such as interactions that could contribute to complex diseases such as cancers that develop over a long period of time. There is a need for assays that can be validated against known human physiological processes. We have previously validated sensitive human cell culture assays for their responsiveness to agents that induce carcinogenesis in vivo. In this initial study we analysed the effects of three batches of reclaimed water on human colonic cells. At concentrations of up to 10-fold, they had no significant effect on the cellular markers, indicating an overall lack of biological activity. The assay has potential but needs to be refined to maximise its sensitivity.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
050206 Environmental Monitoring
Socio Economic Objective 970110 Expanding Knowledge in Technology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, Australian Water Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033328

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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