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Mechanisms involved in the renal responses to intravenous and renal artery infusions of noradrenaline in conscious dogs

Anderson, W. P., Korner, P. I. and Selig, S. E. 1981, Mechanisms involved in the renal responses to intravenous and renal artery infusions of noradrenaline in conscious dogs, Journal of physiology, vol. 321, pp. 21-30.

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Title Mechanisms involved in the renal responses to intravenous and renal artery infusions of noradrenaline in conscious dogs
Author(s) Anderson, W. P.
Korner, P. I.
Selig, S. E.
Journal name Journal of physiology
Volume number 321
Start page 21
End page 30
Publisher Cambridge University Press
Place of publication London, England
Publication date 1981-12
ISSN 0022-3751
1469-7793
Summary 1. The renal haemodynamic and glomerular filtration rate (G.F.R.) responses to intravenous and intrarenal infusions of noradrenaline were studied in conscious dogs, either with or without prior blockade of angiotensin II formation with teprotide.

2. Infusion noradrenaline by either route resulted in dose-related rises in plasma renin activity.

3. Pretreatment with teprotide reduced the rise in mean arterial pressure and abolished the rise in G.F.R. seen during intravenous infusions of noradrenaline (0.1, 0.2 and 0.4 microgram/kg . min). Noradrenaline also reduced filtration fraction more after teprotide pretreatment.

4. Renal blood flow rose and renal vascular resistance fell in response to I.V. noradrenaline infusions. This renal vasodilatation was unaffected by pretreatment of the dogs with teprotide, indomethacin or DL-propranolol. However after pentolinium pretreatment, I.V. noradrenaline infusion caused a dose-related renal vasoconstriction.

5. Infusion of noradrenaline into the renal artery (0.02, 0.05 and 0.1 microgram/kg . min) resulted in rises in mean arterial pressure and G.F.R. which were abolished by teprotide pretreatment. Filtration fraction rose when noradrenaline was administered alone but fell when it was infused after teprotide treatment.

6. Thus angiotensin II formed as the result of increased renin release acted to maintain G.F.R. and filtration fraction during noradrenaline infusion. In addition, I.V. noradrenaline infusions in conscious dogs caused reflex vasodilatation of the renal vasculature.
Notes Reproduced with the kind permission of the copyright owner.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1981, Cambridge University Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033411

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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