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Role of angiotensin II in the hypertension induced by renal artery stenosis

Anderson, W. P., Selig, S. E. and Korner, P. I. 1984, Role of angiotensin II in the hypertension induced by renal artery stenosis, Clinical and experimental hypertension, vol. 6, no. 1-2, pp. 299-314, doi: 10.3109/10641968409062567.

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Title Role of angiotensin II in the hypertension induced by renal artery stenosis
Author(s) Anderson, W. P.
Selig, S. E.ORCID iD for Selig, S. E. orcid.org/0000-0003-4159-5111
Korner, P. I.
Journal name Clinical and experimental hypertension
Volume number 6
Issue number 1-2
Start page 299
End page 314
Publisher Informa Healthcare
Place of publication New York, N. Y.
Publication date 1984
ISSN 1064-1963
1525-6006
Keyword(s) enalapril
cardiac output
renal blood flow
renin
one-kidney hypertension
Summary Identical degrees of renal artery stenosis were induced in 5 dogs on two separate occasions; once during continuous inhibition of angiotensin I converting enzyme with enalapril, and once with the dogs untreated. Arterial pressure rose about 25 mm Hg during 3 days of stenosis in untreated dogs, due to increased total peripheral resistance. When the dogs were treated with enalapril, blood pressure had risen 14.5 ± 3.4 mm Hg 24 hours after stenosis due to a 35% increase in cardiac output while total peripheral resistance fell by 16%. By the third day, blood pressure had returned to pre-stenosis levels, cardiac output was close to normal and total peripheral resistance had increased. The stenosis on the renal artery increased the resistance to blood flow of the kidneys in both untreated and enalapril treated dogs. This increase in kidney resistance in the untreated dogs accounted for about 30% of the change in total peripheral resistance. In the enalapril treated dogs, the increased kidney resistance helped offset the vasodilatation in the rest of the vasculature. These results suggest that angiotensin II mediated vasoconstriction of nonrenal vascular beds was responsible for about ⅔ of the hypertension following renal artery stenosis, and the resistance of the stenosis responsible for about ⅓.
Language eng
DOI 10.3109/10641968409062567
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1984, Marcel Dekker
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033413

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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