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Renal responses to angiotensin II in conscious dogs : effects of aspirin and indomethacin

Anderson, W. P., Selig, S. E., Woods, R. L. and Gilchrist, A. I. 1987, Renal responses to angiotensin II in conscious dogs : effects of aspirin and indomethacin, Clinical and experimental pharmacology and physiology, vol. 14, no. 8, pp. 641-647.

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Title Renal responses to angiotensin II in conscious dogs : effects of aspirin and indomethacin
Author(s) Anderson, W. P.
Selig, S. E.
Woods, R. L.
Gilchrist, A. I.
Journal name Clinical and experimental pharmacology and physiology
Volume number 14
Issue number 8
Start page 641
End page 647
Publisher Blackwell Publishing Asia Pty Ltd
Place of publication Carlton, Vic.
Publication date 1987-08
ISSN 0305-1870
1440-1681
Keyword(s) glomerular filtration rate
prostaglandins
renal blood flow
sodium excretion rate
Summary 1. Angiotensin II was infused into the renal artery of unanaesthetized dogs at 0.4 and 2.0 ng/kg per min for 40 min each.

2. Indomethacin (3 mg/kg, and 1 mg/kg per h infusion i.v.) accentuated the angiotensin II-induced falls in glomerular filtration rate, renal blood flow and urine flow rate. Indomethacin did not alter the effects of angiotensin II on Na+ or K+ excretions.

3. Aspirin (35 mg/kg p.o. 2.5 h and 0.5 h prior to experiment) did not significantly change the renal effects of angiotensin II.

4. Both aspirin and indomethacin accentuated renal vasoconstriction during briefer (5 min) angiotensin II infusion.

5. Thus indomethacin and aspirin had markedly different effects on the actions of angiotensin II in the kidney. This suggests that at least one of these drugs has actions which affect angiotensin II-mediated vasoconstriction other than via cyclooxygenase inhibition.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1987, Blackwell Publishing Asia
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033414

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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