Inflammation, hepatic enzymes and resistance training in individuals with metabolic risk factors

Levinger, I., Goodman, C. A., Peake, J., Garnham, A., Hare, D. L., Jerums, G. and Selig, S. 2009, Inflammation, hepatic enzymes and resistance training in individuals with metabolic risk factors, Diabetic medicine, vol. 26, no. 3, pp. 220-227.

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Title Inflammation, hepatic enzymes and resistance training in individuals with metabolic risk factors
Author(s) Levinger, I.
Goodman, C. A.
Peake, J.
Garnham, A.
Hare, D. L.
Jerums, G.
Selig, S.
Journal name Diabetic medicine
Volume number 26
Issue number 3
Start page 220
End page 227
Total pages 8
Publisher Wiley
Place of publication Chichester, England
Publication date 2009-03
ISSN 0742-3071
1464-5491
Keyword(s) cytokines
liver enzymes
metabolic risk factors
weight training
Summary Aims Increases in inflammatory markers, hepatic enzymes and physical inactivity are associated with the development of the metabolic syndrome (MetS). We examined whether inflammatory markers and hepatic enzymes are correlated with traditional risk factors for MetS and studied the effects of resistance training (RT) on these emerging risk factors in individuals with a high number of metabolic risk factors (HiMF, 2.9 ± 0.8) and those with a low number of metabolic risk factors (LoMF, 0.5 ± 0.5).

Methods Twenty-eight men and 27 women aged 50.8 ± 6.5 years (mean ± sd) participated in the study. Participants were randomized to four groups, HiMF training (HiMFT), HiMF control (HiMFC), LoMF training (LoMFT) and LoMF control (LoMFC). Before and after 10 weeks of RT [3 days/week, seven exercises, three sets with intensity gradually increased from 40–50% of one repetition maximum (1RM) to 75–85% of 1RM], blood samples were obtained for the measurement of pro-inflammatory cytokines, C-reactive protein (CRP), -glutamyltransferase (GGT) and alanine aminotransferase (ALT).

Results At baseline, HiMF had higher interleukin-6 (33.9%), CRP (57.1%), GGT (45.2%) and ALT (40.6%) levels, compared with LoMF (all P < 0.05). CRP, GGT and ALT correlated with the number of risk factors (r = 0.48, 0.51 and 0.57, respectively, all P < 0.01) and with other anthropometric and clinical measures (r range from 0.26 to 0.60, P < 0.05). RT did not significantly alter inflammatory markers or hepatic enzymes (all P > 0.05).

Conclusions HiMF was associated with increased inflammatory markers and hepatic enzyme concentrations. RT did not reduce inflammatory markers and hepatic enzymes in individuals with HiMF.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033424

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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