Oxygen (O2) kinetics during early recovery from peak exercise in patients with type 2 diabetes

Levinger, I., Varley, M., Jerums, G., Hare, D. L. and Selig, S. 2011, Oxygen (O2) kinetics during early recovery from peak exercise in patients with type 2 diabetes, Diabetic medicine, vol. 28, no. 5, pp. 612-617.

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Title Oxygen (O2) kinetics during early recovery from peak exercise in patients with type 2 diabetes
Formatted title Oxygen (O2) kinetics during early recovery from peak exercise in patients with type 2 diabetes
Author(s) Levinger, I.
Varley, M.
Jerums, G.
Hare, D. L.
Selig, S.
Journal name Diabetic medicine
Volume number 28
Issue number 5
Start page 612
End page 617
Publisher Wiley
Place of publication Chichester, England
Publication date 2011-05
ISSN 0742-3071
1464-5491
Keyword(s) aerobic power
O2 recovery
Type 2 diabetes
Summary Aims To examine the oxygen (O2) kinetics during early recovery from peak exercise in patients with Type 2 diabetes and to examine whether oxygen O2 recovery is associated with fasting glucose and HbA1c in this population.

Methods Eighty-nine participants (52 men) aged 51.8 ± 7.1 years (mean ± sd) were divided into three groups: normal weight (BMI ≤ 25.0 kg/m2), overweight/obese without diabetes (BMI ≥ 26 kg/m2) and overweight/obese with Type 2 diabetes. Participants were assessed for their aerobic power (VO2peak) on a cycle ergometer, provided a fasting blood sample and underwent a series of anthropometric measurements. Early recovery period was measured for 60 s from cessation of exercise and expressed as percentage of VO2peak (higher percentage represents slower recovery).

Results No significant differences were observed for age between the three study groups. Both the overweight/obese groups without diabetes and with Type 2 diabetes had higher BMI than the normal weight group, with no significant differences between overweight/obese participants without diabetes and those with diabetes. Participants with Type 2 diabetes had lower VO2peak than overweight/obese participants without diabetes and normal weight individuals (19.6 ± 4.8, 22.6 ± 5.4 and 25.7 ± 5.3 ml kg−1 min−1, respectively, P < 0.004 for overall trends). Participants with Type 2 diabetes also had slower recovery in oxygen O2 kinetics after exercise, compared with both normal weight and overweight/obese individuals without diabetes (56.5 ± 7.7, 49.2 ± 7.2, 47.7 ± 7.4%, P < 0.004 for overall trends). Multiple regression analysis revealed that percentage of oxygen O2 recovery was a stronger predictor than VO2peak, BMI or age for fasting glucose and HbA1c.

Conclusions Patients with Type 2 diabetes have lower VO2peak and prolonged oxygen O2 recovery from peak exercise. However, only prolonged oxygen O2 recovery was associated with fasting glucose and HbA1c.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033427

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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