Creatine supplementation increases muscle total creatine but not maximal intermittent exercise performance

McKenna, Michael J., Morton, Judith, Selig, Steve E. and Snow, Rodney J. 1999, Creatine supplementation increases muscle total creatine but not maximal intermittent exercise performance, Journal of applied physiology, vol. 87, no. 6, pp. 2244-2252.

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Title Creatine supplementation increases muscle total creatine but not maximal intermittent exercise performance
Author(s) McKenna, Michael J.
Morton, Judith
Selig, Steve E.
Snow, Rodney J.
Journal name Journal of applied physiology
Volume number 87
Issue number 6
Start page 2244
End page 2252
Publisher American Physiological Society
Place of publication [Bethesda, Md.]
Publication date 1999-12-01
ISSN 8750-7587
1522-1601
Keyword(s) ergogenic aids
creatine washout
muscle performance
fatigue
Summary This study investigated creatine supplementation (CrS) effects on muscle total creatine (TCr), creatine phosphate (CrP), and intermittent sprinting performance by using a design incorporating the time course of the initial increase and subsequent washout period of muscle TCr. Two groups of seven volunteers ingested either creatine [Cr; 6 × (5 g Cr-H2O + 5 g dextrose)/day)] or a placebo (6 × 5 g dextrose/day) over 5 days. Five 10-s maximal cycle ergometer sprints with rest intervals of 180, 50, 20, and 20 s and a resting vastus lateralis biopsy were conducted before and 0, 2, and 4 wk after placebo or CrS. Resting muscle TCr, CrP, and Cr were unchanged after the placebo but were increased (P < 0.05) at 0 [by 22.9 ± 4.2, 8.9 ± 1.9, and 14.0 ± 3.3 (SE) mmol/kg dry mass, respectively] and 2 but not 4 wk after CrS. An apparent placebo main effect of increased peak power and cumulative work was found after placebo and CrS, but no treatment (CrS) main effect was found on either variable. Thus, despite the rise and washout of muscle TCr and CrP, maximal intermittent sprinting performance was unchanged by CrS.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1999, American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033429

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