Differential response to resistance training in CHF according to ACE genotype

Williams, Andrew D., Anderson, Mitchell J., Selig, Steve, Carey, Michael F., Febbraio, Mark A., Hayes, Alan, Toia, Deidre, Harrap, Stephen B. and Hare, David L. 2011, Differential response to resistance training in CHF according to ACE genotype, International journal of cardiology, vol. 149, no. 3, pp. 330-334.

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Title Differential response to resistance training in CHF according to ACE genotype
Author(s) Williams, Andrew D.
Anderson, Mitchell J.
Selig, Steve
Carey, Michael F.
Febbraio, Mark A.
Hayes, Alan
Toia, Deidre
Harrap, Stephen B.
Hare, David L.
Journal name International journal of cardiology
Volume number 149
Issue number 3
Start page 330
End page 334
Total pages 5
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2011-06-16
ISSN 0167-5273
1874-1754
Keyword(s) heart failure
genes
exercise
Summary Background : The Angiotensin Converting Enzyme (ACE) gene may influence the risk of heart disease and the response to various forms of exercise training may be at least partly dependent on the ACE genotype. We aimed to determine the effect of ACE genotype on the response to moderate intensity circuit resistance training in chronic heart failure (CHF) patients.

Methods :
The relationship between ACE genotype and the response to 11 weeks of resistance exercise training was determined in 37 CHF patients (New York Heart Association Functional Class = 2.3 ± 0.5; left ventricular ejection fraction 28 ± 7%; age 64 ± 12 years; 32:5 male:female) who were randomised to either resistance exercise (n = 19) or inactive control group (n = 18). Outcome measures included VO2peak power output and muscle strength and endurance. ACE genotype was determined using standard methods.

Results :
At baseline, patients who were homozygous for the I allele had higher VO2peak (p = 0.02) and peak power (p = 0.003) compared to patients who were homozygous for the D allele. Patients with the D allele, who were randomised to resistance training, compared to non-exercising controls, had greater peak power increases (ID p < 0.001; DD p < 0.001) when compared with patients homozygous for the I allele, who did not improve. No significant genotype-dependent changes were observed in VO2peak, muscle strength, muscle endurance or lactate threshold.

Conclusion :
ACE genotype may have a role in exercise tolerance in CHF and could also influence the effectiveness of resistance training in this condition.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033448

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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