Antiamnesic effect of stevioside in scopolamine-treated rats

Sharma, Deepika, Puri, Munish, Tiwary, Ashok K., Singh, Nirmal and Jaggi, Amteshwar Singh 2010, Antiamnesic effect of stevioside in scopolamine-treated rats, Indian journal of pharmacology, vol. 42, no. 3, May-June, pp. 164-167.

Attached Files
Name Description MIMEType Size Downloads

Title Antiamnesic effect of stevioside in scopolamine-treated rats
Author(s) Sharma, Deepika
Puri, Munish
Tiwary, Ashok K.
Singh, Nirmal
Jaggi, Amteshwar Singh
Journal name Indian journal of pharmacology
Volume number 42
Issue number 3
Season May-June
Start page 164
End page 167
Total pages 4
Publisher Medknow Publications and Media
Place of publication Mumbai, India
Publication date 2010-06
ISSN 0253-7613
1998-3751
Keyword(s) memory
Morris water-maze
scopolamine
stevioside
Summary The present study was undertaken to explore the potential of Stevioside in memory dysfunction of rats. Memory impairment was produced by Scopolamine (0.5 mg/kg, i.p.) in animals. Morris water-maze test was employed to assess learning and memory. Brain acetylcholinestrase enzyme (AChE) activity was measured to assess central cholinergic activity. The levels of brain thio-barbituric acid reactive species (TBARS) and reduced glutathione (GSH) were estimated to assess degree of oxidative stress. Scopolamine administration induced significant impairment of learning and memory in rats as indicated by marked decrease in Morris water-maze performance. Scopolamine administration also produced a significant enhancement of brain AChE activity and brain oxidative stress (increase in TBARS & decrease in GSH) levels. Pretreatment of Stevioside (250mg/kg dose orally) significantly reversed Scopolamine induced learning & memory deficits along with attenuation of Scopolamine induced rise in brain AChE activity and brain oxidative stress levels. It may be concluded that Stevioside exerts memory preservative effect in cognitive deficits of rats possibly through its multiple actions.
Language eng
Field of Research 090803 Food Nutritional Balance
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2010
Copyright notice ©2010, Medknow Publications Pvt. Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033613

Document type: Journal Article
Collection: Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin)
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 13 times in TR Web of Science
Scopus Citation Count Cited 18 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 196 Abstract Views, 4 File Downloads  -  Detailed Statistics
Created: Wed, 23 Mar 2011, 10:55:08 EST by Munish Puri

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.