Anti-amnesic effect of enzyme extracted stevioside from Stevia rebaudiana

Puri, Munish, Sharma, Deepika, Singh, Nirmal and Tiwary, A. K. 2010, Anti-amnesic effect of enzyme extracted stevioside from Stevia rebaudiana, in IABC 2010 : Abstracts from the 7th Indo-Australia Biotechnology conference 2010, IABC, Brisbane, Qld., pp. 50-50.

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Title Anti-amnesic effect of enzyme extracted stevioside from Stevia rebaudiana
Formatted title Anti-amnesic effect of enzyme extracted stevioside from Stevia rebaudiana
Author(s) Puri, MunishORCID iD for Puri, Munish
Sharma, Deepika
Singh, Nirmal
Tiwary, A. K.
Conference name Indo-Australia Biotechnology. Conference (7th : 2010 : Brisbane, Queensland)
Conference location Brisbane, Queensland
Conference dates 25-27 Oct. 2010
Title of proceedings IABC 2010 : Abstracts from the 7th Indo-Australia Biotechnology conference 2010
Editor(s) Khanna, Rajiv
Publication date 2010
Start page 50
End page 50
Publisher IABC
Place of publication Brisbane, Qld.
Summary The increasing consumption of sucrose has resulted in several nutritional and medicinal problems, including obesity. There is an alarming rise in the prevalence of obesity, type 2 diabetes mellitus, and metabolic syndrome in children and adults around the world, partly related to increasing availability of energy-dense, high-calorie foods, and perhaps to increased consumption of sugar and particularly fructose sweetened beverages. Therefore, low calorie sweeteners are urgently required to substitute table sugar.

Stevioside, a diterpene glycoside, is well known for its intense sweetness and is used as a non-caloric sweetener. Its potential widespread use requires an easy and effective extraction method. Enzymatic extraction of stevioside from Stevia rebaudiana leaves with cellulase, pectinase and hemicellulase using various parameters such as concentration of enzyme, incubation time and temperature was optimized. The extraction conditions were further optimized using response surface methodology (RSM). Under the optimized conditions, the experimental values were in close agreement with predicted model and resulted in a three times yield enhancement of stevioside.

Various studies have revealed that in addition to sweetening nature of stevisoide, it exerts beneficial effects including antihypertensive, anti-hyperglycemic, anti-human rotavirus, antioxidant, anti-inflammatory and antitumor actions. Its anti-amnesic potential remains to be explored, therefore the present study has been undertaken to investigate the beneficial effect of stevioside in memory deficit of rats employing scopolamine induced amnesia as an animal model.

Significance: Stevia is gaining significance in different parts of the world and is expected to develop into a major source of high potency sweetener for the growing natural food market. There is a strong possibility that Stevia sweeteners could replace aspartame in some diet variants. In addition, Stevia is expected to be used as a part substitute for sugar and also used in combination with other artificial sweeteners in the emerging phase of life cycle.
Language eng
Field of Research 100302 Bioprocessing, Bioproduction and Bioproducts
Socio Economic Objective 920411 Nutrition
HERDC Research category E3 Extract of paper
HERDC collection year 2010
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Created: Wed, 23 Mar 2011, 12:12:27 EST by Munish Puri

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