Ribosome inactivating proteins (RIPs) : a promising candidate for industrial biotechnology

Puri, Munish, Kaur, Inderdeep and Batra, J. K. 2009, Ribosome inactivating proteins (RIPs) : a promising candidate for industrial biotechnology, in Proceedings of the 2009 Bangalore Bio conference, The Conference, [Bangalore, India], pp. 71-71.

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Title Ribosome inactivating proteins (RIPs) : a promising candidate for industrial biotechnology
Author(s) Puri, Munish
Kaur, Inderdeep
Batra, J. K.
Conference name Bangalore Bio. Conference (2009 : Bangalore, India)
Conference location Bangalore, India
Conference dates 18-20 Jun. 2009
Title of proceedings Proceedings of the 2009 Bangalore Bio conference
Publication date 2009
Start page 71
End page 71
Publisher The Conference
Place of publication [Bangalore, India]
Summary The ribosome inactivating proteins (RIPs) from plants possess RNA N- glycosidase activity that depurinates the major rRNA, thus damaging ribosomes in an irreversible manner and arresting protein synthesis. RIPs are presently classified as rRNA N-glycosidase in the enzyme nomenclature (EC 3.2.2.22) and do exhibit other enzymatic activities such as ribonuclease and deoxyribonuclease activities. RIPs have been shown to manifest anti-tumor, anti-viral and anti-microbial activities. RIPs are detected in some medicinal plants but the yields are insufficient to warrant their availability to conduct clinical trials thus limiting its therapeutic potential. Here, an approach based on "bioprocess development" shall be discussed that may enhance the yield of RIPs. It is anticipated; with the involvement of “Industrial biotechnology” the eventual availability of RIPs in large quantities shall be accomplished.
Language eng
Field of Research 100302 Bioprocessing, Bioproduction and Bioproducts
Socio Economic Objective 860802 Human Diagnostics
HERDC Research category E2.1 Full written paper - non-refereed / Abstract reviewed
ERA Research output type X Not reportable
HERDC collection year 2009
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033630

Document type: Conference Paper
Collection: Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin)
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