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Ribosome inactivating proteins purification from a medicinal plant

Puri, Munish 2009, Ribosome inactivating proteins purification from a medicinal plant, in Proceedings of the 10th Anniversary Protein Expression Workshop 2009, The Workshop, [Melbourne, Vic.].

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Title Ribosome inactivating proteins purification from a medicinal plant
Author(s) Puri, Munish
Conference name Anniversary Protein Expression Workshop (10th : 2009 : Melbourne, Victoria)
Conference location Melbourne, Victoria
Conference dates 4-7 Aug. 2009
Title of proceedings Proceedings of the 10th Anniversary Protein Expression Workshop 2009
Editor(s) Lovercz, George
Publication date 2009
Publisher The Workshop
Place of publication [Melbourne, Vic.]
Summary The ribosome inactivating proteins (RIPs) from plants possess RNA N- glycosidase activity that depurinates the major rRNA, thus damaging ribosomes in an irreversible manner and arresting protein synthesis. RIPs are presently classified as rRNA N-glycosidase in the enzyme nomenclature (EC 3.2.2.22) and do exhibit other enzymatic activities such as ribonuclease and deoxyribonuclease activities. RIPs have been shown to manifest abortifacient, anti-tumor, anti-viral and anti-microbial activities. RIPs are detected in some medicinal plants but the yields are insufficient to warrant their availability to conduct clinical trials for therapeutic application. Here, we describe an approach based on “bioprocess development” that may enhance the yield of RIPs and eventually their availability for exploiting their therapeutic potential.
Language eng
Field of Research 100302 Bioprocessing, Bioproduction and Bioproducts
Socio Economic Objective 860105 Nutraceuticals and Functional Foods
HERDC Research category E2.1 Full written paper - non-refereed / Abstract reviewed
ERA Research output type X Not reportable
Persistent URL http://hdl.handle.net/10536/DRO/DU:30033632

Document type: Conference Paper
Collection: Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin)
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Created: Wed, 23 Mar 2011, 14:38:58 EST by Munish Puri