Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise

Wallace, Marita A., Hock, M. Benjamin, Hazen, Bethany C., Kralli, Anastasia, Snow, Rod J. and Russell, Aaron P. 2011, Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise, Journal of physiology, vol. 589, no. 8, pp. 2027-2039.

Attached Files
Name Description MIMEType Size Downloads

Title Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise
Author(s) Wallace, Marita A.
Hock, M. Benjamin
Hazen, Bethany C.
Kralli, Anastasia
Snow, Rod J.
Russell, Aaron P.
Journal name Journal of physiology
Volume number 589
Issue number 8
Start page 2027
End page 2039
Publisher Cambridge University Press
Place of publication London, England
Publication date 2011-04
ISSN 0022-3751
1469-7793
Summary Exercise improves the ability of skeletal muscle to metabolise fats and sugars. For these improvements to occur the muscle detects a signal caused by exercise, resulting in changes in genes and proteins that control metabolism. We show that endurance exercise increases the amount of a protein called striated muscle activator of Rho signalling (STARS) as well as several other proteins influenced by STARS.We also show that the amount of STARS can be increased by signals directed from proteins called peroxisome proliferator-activated receptor gamma co-activator 1-α (PGC-1α) and oestrogen-related receptor-α (ERRα). We also observed that when we reduce the amount of STARS in muscle cells, we block the ability of PGC-1α/ERRα to increase a gene called carnitine palmitoyltransferase-1β (CPT-1β), which is important for fat metabolism. Our study has shown that the STARS pathway is regulated by endurance exercise. STARS may also play a role in fat metabolism in muscle.
Language eng
Field of Research 111699 Medical Physiology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, The Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30034597

Document type: Journal Article
Collection: Centre for Physical Activity and Nutrition Research
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 16 times in TR Web of Science
Scopus Citation Count Cited 19 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 109 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Tue, 17 May 2011, 12:01:42 EST by Jane Moschetti

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.