You are not logged in.

Analysis of self-assembled monolayer interfaces by electrospray mass spectrometry : a gentle approach

Yang, Wenrong, Zhang, Rui, Willett, Gary D., Hibbert, D. Brynn and Gooding, J. Justin 2003, Analysis of self-assembled monolayer interfaces by electrospray mass spectrometry : a gentle approach, Analytical chemistry, vol. 75, no. 23, pp. 6741-6744, doi: 10.1021/ac0345897.

Attached Files
Name Description MIMEType Size Downloads

Title Analysis of self-assembled monolayer interfaces by electrospray mass spectrometry : a gentle approach
Author(s) Yang, WenrongORCID iD for Yang, Wenrong orcid.org/0000-0001-8815-1951
Zhang, Rui
Willett, Gary D.
Hibbert, D. Brynn
Gooding, J. Justin
Journal name Analytical chemistry
Volume number 75
Issue number 23
Start page 6741
End page 6744
Publisher American Chemical Society
Place of publication Washington, D.C.
Publication date 2003
ISSN 0003-2700
1520-6882
Summary A general mass spectrometry technique for the characterization of alkanethiol-modified surfaces is presented. Alkanethiol self-assembled onto a gold surface (in this case, peptides were attached to the gold surface via a thiolate bond) was reductively desorbed in 0.05 M KOH in the presence of octadecyl-derivatized silica gel. The peptide adsorbed onto the silica gel, whereupon it could be filtered, washed to remove any salts, and then eluted using a mixture of 4:1 v/v methanol/water. The eluant containing the peptide was injected into a Fourier transform ion-cyclotron resonance mass spectrometer (FTICR/MS) via electrospray ionization. The spectrum showed no fragmentation of the peptide, demonstrating the gentleness of the technique. This simple procedure is not limited to FTICR/MS and could be adapted to other mass spectrometers.
Language eng
DOI 10.1021/ac0345897
Field of Research 100703 Nanobiotechnology
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2003, American Chemical Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30034968

Document type: Journal Article
Collection: Institute for Technology Research and Innovation
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 10 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 239 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Mon, 30 May 2011, 10:55:12 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.