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Stepwise synthesis of Gly−Gly−His on gold surfaces modified with mixed self-assembled monolayers

Yang, Wenrong R., Hibbert, D. Brynn, Zhang, Rui, Willett, Gary D. and Gooding, J. Justin 2005, Stepwise synthesis of Gly−Gly−His on gold surfaces modified with mixed self-assembled monolayers, Langmuir, vol. 21, no. 1, pp. 260-265, doi: 10.1021/la0482599.

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Title Stepwise synthesis of Gly−Gly−His on gold surfaces modified with mixed self-assembled monolayers
Author(s) Yang, Wenrong R.ORCID iD for Yang, Wenrong R. orcid.org/0000-0001-8815-1951
Hibbert, D. Brynn
Zhang, Rui
Willett, Gary D.
Gooding, J. Justin
Journal name Langmuir
Volume number 21
Issue number 1
Start page 260
End page 265
Publisher American Chemical Society
Place of publication Washington, D.C.
Publication date 2005-01-04
ISSN 0743-7463
1520-5827
Summary Peptide-modified electrode surfaces have been shown to have excellent recognition properties for metal ions. An efficient method of screening a potential peptide for its selectivity for a given metal would involve the synthesis of the peptide directly on the electrode surface. This paper outlines a procedure in which the tripeptide Gly−Gly−His was synthesized one amino acid at a time on a gold surface modified with a self-assembled monolayer of the mixed alkanethiolates 3-mercaptopropionic acid (MPA) and 3-mercaptopropane (MP). Electrochemistry and high-resolution mass spectrometry were used to elucidate the structure of the adsorbed species and follow the synthesis. The amino acids can be attached only to MPA, but the presence of a diluting unreactive molecule of MP reduces steric crowding about the reaction center. The maximum coverage of synthesized tripeptide occurs at a ratio of MPA/MP of 1:1.
Language eng
DOI 10.1021/la0482599
Field of Research 100703 Nanobiotechnology
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2005, American Chemical Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30034976

Document type: Journal Article
Collection: Institute for Technology Research and Innovation
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