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Parameters important in fabricating enzyme electrodes using self-assembled monolayers of alkanethiols

Gooding, J. Justin, Erokhin, Paul, Losic, Dusan, Yang, Wenrong, Policarpio, Vanessa, Liu, Jingquan, Ho, Felix M., Situmorang, Manihar, Hibbert, D. Brynn and Shapter, Joe G. 2001, Parameters important in fabricating enzyme electrodes using self-assembled monolayers of alkanethiols, Analytical sciences, vol. 17, no. 1, pp. 3-9.

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Title Parameters important in fabricating enzyme electrodes using self-assembled monolayers of alkanethiols
Author(s) Gooding, J. Justin
Erokhin, Paul
Losic, Dusan
Yang, WenrongORCID iD for Yang, Wenrong orcid.org/0000-0001-8815-1951
Policarpio, Vanessa
Liu, Jingquan
Ho, Felix M.
Situmorang, Manihar
Hibbert, D. Brynn
Shapter, Joe G.
Journal name Analytical sciences
Volume number 17
Issue number 1
Start page 3
End page 9
Publisher Japan Society for Analytical Chemistry
Place of publication Tokyo, Japan
Publication date 2001
ISSN 1348-2246
0910-6340
Summary The fabrication of enzyme electrodes using self-assembled monolayers (SAMs) has attracted considerable interest because of the spatial control over the enzyme immobilization. A model system of glucose oxidase covalently bound to a gold electrode modified with a SAM of 3-mercaptopropionic acid was investigated with regard to the effect of fabrication variables such as the surface topography of the underlying gold electrode, the conditions during covalent attachment of the enzyme and the buffer used. The resultant monolayer enzyme electrodes have excellent sensitivity and dynamic range which can easily be adjusted by controlling the amount of enzyme immobilized. The major drawback of such electrodes is the response which is limited by the kinetics of the enzyme rather than mass transport of substrates. Approaches to bringing such enzyme electrodes into the mass transport limiting regime by exploiting direct electron transfer between the enzyme and the electrode are outlined.
Notes Reproduced with the kind permission of the copyright owner.
Language eng
Field of Research 100703 Nanobiotechnology
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2001, Japan Society for Analytical Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035176

Document type: Journal Article
Collections: Institute for Technology Research and Innovation
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