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Is excess calcium harmful to health?

Daly, Robin M. and Ebeling, Peter R. 2010, Is excess calcium harmful to health?, Nutrients, vol. 2, no. 5, pp. 505-522.

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Title Is excess calcium harmful to health?
Alternative title Review : Is excess calcium harmful to health?
Author(s) Daly, Robin M.
Ebeling, Peter R.
Journal name Nutrients
Volume number 2
Issue number 5
Start page 505
End page 522
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2010-05
ISSN 2072-6643
Keyword(s) calcium supplementation
cardiovascular disease
mortality
elderly
Summary Most current guidelines recommend that older adults and the elderly strive for a total calcium intake (diet and supplements) of 1,000 to 1,300 mg/day to prevent osteoporosis and fractures. Traditionally, calcium supplements have been considered safe, effective and well tolerated, but their safety has recently been questioned due to potential adverse effects on vascular disease which may increase mortality. For example, the findings from a meta-analysis of randomized controlled trials (currently published in abstract form only) revealed that the use of calcium supplements was associated with an ~30% increased risk of myocardial infarction. If high levels of calcium are harmful to health, this may alter current public health recommendations with regard to the use of calcium supplements for preventing osteoporosis. In this review, we provide an overview of the latest information from human observational and prospective studies, randomized controlled trials and meta-analyses related to the effects of calcium supplementation on vascular disease and related risk factors, including blood pressure, lipid and lipoprotein levels and vascular calcification.
Notes Reproduced under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/ “published material can be re-used without obtaining permission as long as a correct citation to the original publication is given” http://www.mdpi.com/about/openaccess
Language eng
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C2.1 Other contribution to refereed journal
Copyright notice ©2010, MDPI
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035193

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