Effects of lifetime loading history on cortical bone density and its distribution in middle-aged and older men

Bailey, Christine A., Kukuljan, Sonja and Daly, Robin M. 2010, Effects of lifetime loading history on cortical bone density and its distribution in middle-aged and older men, Bone, vol. 47, no. 3, pp. 673-680, doi: 10.1016/j.bone.2010.06.027.

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Title Effects of lifetime loading history on cortical bone density and its distribution in middle-aged and older men
Author(s) Bailey, Christine A.
Kukuljan, Sonja
Daly, Robin M.ORCID iD for Daly, Robin M. orcid.org/0000-0002-9897-1598
Journal name Bone
Volume number 47
Issue number 3
Start page 673
End page 680
Total pages 8
Publisher Elsevier
Place of publication New York, N. Y.
Publication date 2010-09
ISSN 8756-3282
Keyword(s) bone mass distribution
bone strength
physical activity
Summary We have reported previously that long-term participation of weight-bearing exercise is associated with increased QCT-derived cortical bone size and strength in middle-aged and older men, but not whole bone cortical volumetric BMD. However, since bone remodeling and the distribution of loading-induced strains within cortical bone are non-uniform, the aim of this study was to examine the effects of lifetime loading history on cortical bone mass distribution and bone shape in healthy community dwelling middle-aged and older men. We used QCT to assess mid-femur and mid-tibia angular bone mass distribution around its center (polar distribution), the bone density distribution through the cortex (radial distribution), and the ratio between the maximum and minimum moments of inertia (Imax/Imin ratio) in 281 men aged 50 to 79 years. Current (> 50 years) and past (13–50 years) sport and leisure time activity was assessed by questionnaire to calculate an osteogenic index (OI) during adolescence and adulthood. All men were then categorized into a high (H) or low/non impact (L) group according to their OI scores in each period. Three contrasting groups were then formed to reflect weight-bearing impact categories during adolescence and then adulthood: H–H, H–L and L–L. For polar bone mass distribution, bone deposition in the anterolateral, medial and posterior cortices were 6–10% greater at the mid-femur and 9–24% greater at mid-tibia in men in the highest compared to lowest tertile of lifetime loading (p < 0.01– < 0.001). When comparing the influence of contrasting loading history during adolescence and adulthood, there was a graded response between the groups in the distribution of bone mass at the anterior-lateral and posterior regions of the mid-tibia (H–H > H–L > L–L). For radial bone density distribution, there were no statistically significant effects of loading at the mid-femur, but a greater lifetime OI was associated with a non-significant 10–15% greater bone density near the endocortical region of the mid-tibia. In conclusion, a greater lifetime loading history was associated with region-specific adaptations in cortical bone density.
Language eng
DOI 10.1016/j.bone.2010.06.027
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Grant ID NHMRC 425849
Copyright notice ©2010, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035240

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