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Nail-biting stuff? The effect of N-acetyl cysteine on nail-biting

Berk, Michael, Jeavons, Sue, Dean, Olivia M., Dodd, Seetol, Moss, Kirsteen, Gama, Clarissa S. and Malhi, Gin S. 2009, Nail-biting stuff? The effect of N-acetyl cysteine on nail-biting, CNS spectrums, vol. 14, no. 7, pp. 357-360.

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Title Nail-biting stuff? The effect of N-acetyl cysteine on nail-biting
Author(s) Berk, Michael
Jeavons, Sue
Dean, Olivia M.
Dodd, Seetol
Moss, Kirsteen
Gama, Clarissa S.
Malhi, Gin S.
Journal name CNS spectrums
Volume number 14
Issue number 7
Start page 357
End page 360
Total pages 4
Publisher MBL Communications
Place of publication New York, N.Y.
Publication date 2009-07
ISSN 1092-8529
Keyword(s) nail biting
Summary N-acetyl cysteine (NAC) is a widely available nutraceutical with a variety of actions. As a precursor of cysteine and glutathione, it has antioxidant properties that may impact on mood and contribute to an effect on impulsivity and obsessive behaviour. Via its additional effect on glutamate via the cystine-glutamate exchange system, NAC has been shown to mediate impulsivity in preclinical models of addiction, reduce craving, and cue extinction. Further, by boosting glutathione, NAC acts as a potent antioxidant and has been shown in two positive, large-scale randomized placebo-controlled trials to affect negative symptoms in schizophrenia and depression in bipolar disorder. We describe three cases in which its actions specifically on nail-biting and associated anxiety may offer a potential treatment. The spontaneous findings are reported as part of an ongoing treatment trial examining the utility of NAC in bipolar disorder. Its actions, if robustly replicated, also point to potential treatment targets in glutathione or glutamate pathways in the brain.
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Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, MBL Communications
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035461

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.