Glutathione : a novel treatment target in psychiatry

Berk, Michael, Ng, Felicity, Dean, Olivia, Dodd, Seetal and Bush, Ashley I. 2008, Glutathione : a novel treatment target in psychiatry, Trends in pharmacological sciences, vol. 29, no. 7, pp. 346-351.

Attached Files
Name Description MIMEType Size Downloads

Title Glutathione : a novel treatment target in psychiatry
Author(s) Berk, Michael
Ng, Felicity
Dean, Olivia
Dodd, Seetal
Bush, Ashley I.
Journal name Trends in pharmacological sciences
Volume number 29
Issue number 7
Start page 346
End page 351
Total pages 6
Publisher Elsevier
Place of publication London, England
Publication date 2008-07
ISSN 0165-6147
1873-3735
Summary There is accumulating evidence for oxidative stress mechanisms as common pathophysiological pathways in diverse psychiatric disorders, which offers novel treatment targets in oxidation biology systems. Of these the glutathione system has the most favourable theoretical foundation, given its dominance as the most generic of cellular antioxidants. Clinically, this hypothesis has been supported by several recently published studies that have reported on the efficacy of N-acetylcysteine, a glutathione precursor, in the treatment of various psychiatric disorders. This article outlines the multidimensional evidence that currently exists for oxidative stress mechanisms in psychiatric disorders and specifically discusses glutathione as a promising novel therapeutic target.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035464

Document type: Journal Article
Collection: School of Medicine
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 83 times in TR Web of Science
Scopus Citation Count Cited 92 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 70 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Tue, 21 Jun 2011, 14:38:52 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.