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N-acetylcysteine in psychiatry - current therapeutic evidence and potential mechanisms of action

Dean, Olivia, Giorlando, Frank and Berk, Michael 2011, N-acetylcysteine in psychiatry - current therapeutic evidence and potential mechanisms of action, Journal of psychiatry and neuroscience, vol. 36, no. 2, pp. 78-86.

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Title N-acetylcysteine in psychiatry - current therapeutic evidence and potential mechanisms of action
Author(s) Dean, Olivia
Giorlando, Frank
Berk, Michael
Journal name Journal of psychiatry and neuroscience
Volume number 36
Issue number 2
Start page 78
End page 86
Publisher Canadian Medical Association
Place of publication Ottowa, Canada
Publication date 2011
ISSN 1488-2434
1180-4882
Summary There is an expanding field of research investigating the benefits of alternatives to current pharmacological therapies in psychiatry. N-acetylcysteine (NAC) is emerging as a useful agent in the treatment of psychiatric disorders. Like many therapies, the clinical origins of NAC are far removed from its current use in psychiatry. Whereas the mechanisms of NAC are only beginning to be understood, it is likely that NAC is exerting benefits beyond being a precursor to the antioxidant, glutathione, modulating glutamatergic, neurotropic and inflammatory pathways. This review outlines the current literature regarding the use of NAC in disorders including addiction, compulsive and grooming disorders, schizophrenia and bipolar disorder. N-acetylcysteine has shown promising results in populations with these disorders, including those in whom treatment efficacy has previously been limited. The therapeutic potential of this acetylated amino acid is beginning to emerge in the field of psychiatric research.
Notes First published online: June 24, 2010
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, Canadian Medical Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035469

Document type: Journal Article
Collection: School of Medicine
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Created: Tue, 21 Jun 2011, 14:39:14 EST