Oxidative stress in psychiatric disorders : evidence base and therapeutic implications

Ng, Felicity, Berk, Michael, Dean, Olivia and Bush, Ashley I. 2008, Oxidative stress in psychiatric disorders : evidence base and therapeutic implications, International journal of neuropsychopharmacology, vol. 11, no. 6, pp. 851-876.

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Title Oxidative stress in psychiatric disorders : evidence base and therapeutic implications
Author(s) Ng, Felicity
Berk, Michael
Dean, Olivia
Bush, Ashley I.
Journal name International journal of neuropsychopharmacology
Volume number 11
Issue number 6
Start page 851
End page 876
Total pages 26
Publisher Cambridge University Press
Place of publication Cambridge, England
Publication date 2008-01-21
ISSN 1461-1457
1469-5111
Keyword(s) antioxidant
mechanisms
oxidative stress
pathophysiology
psychiatric disorders
Summary Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may be a common pathogenic mechanism underlying many major psychiatric disorders, as the brain has comparatively greater vulnerability to oxidative damage. This review aims to examine the current evidence for the role of oxidative stress in psychiatric disorders, and its academic and clinical implications. A literature search was conducted using the Medline, Pubmed, PsycINFO, CINAHL PLUS, BIOSIS Previews, and Cochrane databases, with a time-frame extending to September 2007. The broadest data for oxidative stress mechanisms have been derived from studies conducted in schizophrenia, where evidence is available from different areas of oxidative research, including oxidative marker assays, psychopharmacology studies, and clinical trials of antioxidants. For bipolar disorder and depression, a solid foundation for oxidative stress hypotheses has been provided by biochemical, genetic, pharmacological, preclinical therapeutic studies and one clinical trial. Oxidative pathophysiology in anxiety disorders is strongly supported by animal models, and also by human biochemical data. Pilot studies have suggested efficacy of N-acetylcysteine in cocaine dependence, while early evidence is accumulating for oxidative mechanisms in autism and attention deficit hyperactivity disorder. In conclusion, multi-dimensional data support the role of oxidative stress in diverse psychiatric disorders. These data not only suggest that oxidative mechanisms may form unifying common pathogenic pathways in psychiatric disorders, but also introduce new targets for the development of therapeutic interventions.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970115 Expanding Knowledge in Commerce, Management, Tourism and Services
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, CINP
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035479

Document type: Journal Article
Collection: School of Medicine
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