Restless leg syndrome caused by olanzapine: a case series

Aggarwal, Shilpa, Dodd, Seetal and Berk, Michael 2010, Restless leg syndrome caused by olanzapine: a case series, Current drug safety, vol. 5, no. 2, pp. 129-131.

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Title Restless leg syndrome caused by olanzapine: a case series
Author(s) Aggarwal, Shilpa
Dodd, Seetal
Berk, Michael
Journal name Current drug safety
Volume number 5
Issue number 2
Start page 129
End page 131
Total pages 3
Publisher Bentham Science Publishers
Place of publication San Francisco, Ca.
Publication date 2010-04
ISSN 1574-8863
2212-3911
Keyword(s) Restless legs syndrome
olanzapine
Summary Restless leg syndrome (RLS) is a common disorder associated with significant distress. We report three cases of drug induced RLS caused by olanzapine. In each case, RLS commenced after initiation of treatment with olanzapine and resolved after ceasing olanzapine. All three patients were subsequently treated with other atypical antipsychotics, risperidone, quetiapine or aripiprazole, without re-emergence of RLS. RLS is associated with central dopaminergic dysfunction. Dopamine agonists and l-dopa reduce the symptoms of RLS, and some agents that block the dopaminergic system aggravate RLS. Greater awareness of potential causes of RLS, and its differentiation from akathisia and illness related agitation might help in reducing the distress associated with it and improving patient compliance.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035517

Document type: Journal Article
Collection: School of Medicine
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