Bipolar II disorder : a review

Berk, Michael and Dodd, Seetal 2005, Bipolar II disorder : a review, Bipolar disorders, vol. 7, no. 1, pp. 11-21.

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Title Bipolar II disorder : a review
Author(s) Berk, Michael
Dodd, Seetal
Journal name Bipolar disorders
Volume number 7
Issue number 1
Start page 11
End page 21
Publisher Wiley - Blackwell
Place of publication Malden, Mass
Publication date 2005-02
ISSN 1398-5647
1399-5618
Keyword(s) bipolar disorder
bipolar II
depression
hypomania
unipolar
Summary Objectives: To review the current knowledge of bipolar II disorder.

Methods: Literature was reviewed after conducting a Medline search and a hand search of relevant literature.

Results: Bipolar II disorder is a common disorder, with a prevalence of approximately 3–5%. Distinct clinical features of bipolar II disorder have been described. The key to diagnosis is the recognition of past hypomania, while depression is the typical presenting feature of the illness. This is responsible for a significant rate of missed diagnosis, and consequent management according to unipolar guidelines. It is unclear if bipolar II disorder is over-represented amongst resistant depression populations and if abrupt offset of antidepressant action is a phenomenon over represented in bipolar II disorder, reflecting induction of predominantly depressive cycling. A few mood-stabilizer studies available provide provisional suggestion of utility. A supportive role for psychosocial therapies is suggested, however, there is a sparsity of published studies specific to bipolar II disorder cohorts. A small number of short-term antidepressant trials have suggested efficacy, however, compelling long-term maintenance data is absent.

Conclusions: An emerging literature on the specific clinical signature and management of the disorder exists, however, this is disproportionately small relative to the epidemiology and clinical significance of the disorder.
Notes Article first published online 14 JAN 2005
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2005, Blackwell Munksgaard
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035529

Document type: Journal Article
Collection: School of Medicine
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