Efficacy of atypical antipsychotics in bipolar disorder

Berk, Michael and Dodd, Seetal 2005, Efficacy of atypical antipsychotics in bipolar disorder, Drugs, vol. 65, no. 2, pp. 257-269.

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Title Efficacy of atypical antipsychotics in bipolar disorder
Author(s) Berk, Michael
Dodd, Seetal
Journal name Drugs
Volume number 65
Issue number 2
Start page 257
End page 269
Publisher Adis International
Place of publication Auckland, New Zealand
Publication date 2005
ISSN 0012-6667
1179-1950
Summary Bipolar disorder is a severe and recurrent disorder. Atypical antipsychotics have emerged as both an alternative and adjunct to conventional mood stabilisers. The manic phase of the illness is the best studied, and it appears that a class effect with regards to efficacy is present in both monotherapy and augmentation studies. Evidence for efficacy of atypical antipsychotics in depression is emerging. At this stage controlled data are available for both olanzapine and quetiapine. Maintenance data demonstrating efficacy are available for olanzapine. Atypical antipsychotics have utility in treating acute agitation and aggression in manic episodes of bipolar disorder. Subgroup analyses from trials treating manic phase bipolar disorder, and an open-label study of rapid cycling, have suggested that atypical antipsychotics may be useful for the treatment of mixed states and rapid cycling. Several studies have suggested that atypical antipsychotics may be useful in treatment-refractory episodes of bipolar disorder. The current available data suggest greater efficacy of the atypical antipsychotics in mania than in depression, although the data are fairly clear that induction of depression is not an issue with the atypical antipsychotics. A number of trials are underway that will hopefully address many of the questions still pending.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2005, Adis Data Information BV
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035530

Document type: Journal Article
Collection: School of Medicine
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