Dopamine dysregulation syndrome : implications for a dopamine hypothesis of bipolar disorder

Berk, M., Dodd, S., Kauer-Sant'Anna, M., Malhi, G. S., Bourin, M., Kapczinski, F. and Norman, T. 2007, Dopamine dysregulation syndrome : implications for a dopamine hypothesis of bipolar disorder, Acta psychiatrica Scandinavica, vol. 116, no. 434, Supplement, pp. 41-49.

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Title Dopamine dysregulation syndrome : implications for a dopamine hypothesis of bipolar disorder
Author(s) Berk, M.
Dodd, S.
Kauer-Sant'Anna, M.
Malhi, G. S.
Bourin, M.
Kapczinski, F.
Norman, T.
Journal name Acta psychiatrica Scandinavica
Volume number 116
Issue number 434
Season Supplement
Start page 41
End page 49
Publisher Wiley-Blackwell Publishing
Place of publication Malden, Ma.
Publication date 2007-10
ISSN 0001-690X
1600-0447
Keyword(s) dopamine
bipolar disorder
cycling
mania depression
Summary Objective: Rational therapeutic development in bipolar is hampered by a lack of pathophysiological model. However, there is a wealth of converging data on the role of dopamine in bipolar disorder. This paper therefore examines the possibility of a dopamine hypothesis for bipolar disorder.

Method: A literature search was conducted using standard search engines Embase, PyschLIT, PubMed and MEDLINE. In addition, papers and book chapters known to the authors were retrieved and examined for further relevant articles.

Results:
Collectively, in excess of 100 articles were reviewed from which approximately 75% were relevant to the focus of this paper.

Conclusion: Pharmacological models suggest a role of increased dopaminergic drive in mania and the converse in depression. In Parkinson’s disease, administration of high-dose dopamine precursors can produce a ‘maniform’ picture, which switches into a depressive analogue on withdrawal. It is possible that in bipolar disorder there is a cyclical process, where increased dopaminergic transmission in mania leads to a secondary down regulation of dopaminergic receptor sensitivity over time. This may lead to a period of decreased dopaminergic transmission, corresponding with the depressive phase, and the repetition of the cycle. This model, if verified, may have implications for rational drug development.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035540

Document type: Journal Article
Collection: School of Medicine
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