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Health-related quality of life and functioning in bipolar disorder : the impact of pharmacotherapy

Berk, Michael, Hallam, Karen, Lucas, Nellie, Kader, Linda, MacNeil, Craig, Hasty, Melissa, Dodd, Seetal, Malhi, Gin and Conus, Philippe 2006, Health-related quality of life and functioning in bipolar disorder : the impact of pharmacotherapy, Expert review of pharmacoeconomics and outcomes research, vol. 6, no. 5, pp. 509-523.

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Title Health-related quality of life and functioning in bipolar disorder : the impact of pharmacotherapy
Author(s) Berk, Michael
Hallam, Karen
Lucas, Nellie
Kader, Linda
MacNeil, Craig
Hasty, Melissa
Dodd, Seetal
Malhi, Gin
Conus, Philippe
Journal name Expert review of pharmacoeconomics and outcomes research
Volume number 6
Issue number 5
Start page 509
End page 523
Publisher Expert Reviews
Place of publication London, England
Publication date 2006-10
ISSN 1473-7167
1744-8379
Keyword(s) atypical antipsychotic
rating scale
quetiapine
mania
health-related quality of life
depression
bipolar disorder
Summary Bipolar disorder has a major deleterious impact on many aspects of a patient's functioning and health-related quality of life. Although the formal measurement of these deficits has been neglected until recently, many well-designed trials now include an assessment of functioning and health-related quality of life using one or more rating scales. This review describes recent developments in the measurement of functioning and health-related quality of life in bipolar disorder, and discusses the evidence that medications that improve symptoms in bipolar disorder also offer clinically relevant benefits in functioning and health-related quality of life. Direct comparisons of the benefits of medications including atypical antipsychotics are problematic due to differences in trial populations, study durations and rating scales. Data from quetiapine trials indicate that this medication offers prompt and sustained improvement of functioning in patients with mania and enhancement of health-related quality of life in patients with bipolar depression, to accompany the significant improvements in mood episodes.
Notes Reproduced with the kind permission of the copyright owner.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, Expert Reviews
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035550

Document type: Journal Article
Collections: School of Medicine
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