Early intervention in bipolar disorders : clinical, biochemical and neuroimaging imperatives

Berk, Michael, Malhi, Gin S., Hallam, Karen, Gama, Clarissa S., Dodd, Seetal, Andreazza, Ana Cristina, Frey, Benício N. and Kapczinski, Flavio 2009, Early intervention in bipolar disorders : clinical, biochemical and neuroimaging imperatives, Journal of affective disorders, vol. 114, pp. 1-13.

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Title Early intervention in bipolar disorders : clinical, biochemical and neuroimaging imperatives
Author(s) Berk, Michael
Malhi, Gin S.
Hallam, Karen
Gama, Clarissa S.
Dodd, Seetal
Andreazza, Ana Cristina
Frey, Benício N.
Kapczinski, Flavio
Journal name Journal of affective disorders
Volume number 114
Start page 1
End page 13
Publisher Elsevier BV
Place of publication Amsterdam, The Netherlands
Publication date 2009-04
ISSN 0165-0327
1573-2517
Keyword(s) diagnosis
early intervention
bipolar disorders
mania
depression
neuroprotection
Summary In the absence of clear targets for primary prevention of many psychiatric illnesses, secondary prevention becomes the most feasible therapeutic target, and is best encompassed by the concept of early intervention. This construct encompasses the goals of minimising diagnostic delay and the prompt initiation of clinically appropriate therapy. This paper develops the rationale for early intervention in bipolar disorder. Three interrelated themes are discussed; the clinical data supporting the value of prompt diagnosis and treatment in bipolar disorder, the putative biochemical mechanisms underlying the pathophysiological processes, and the parallel concept of neuroprotection, and the developing neuroimaging data that supports early intervention. Early initiation of appropriate therapy may potentially facilitate improved clinical outcomes, and further might allow the secondary prevention of the sequelae of untreated illness, which include the deleterious impact on family relationships, psychosexual and vocational development, identity and self-concept and self-stigma.
Language eng
Field of Research 111714 Mental Health
Socio Economic Objective 920410 Mental Health
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035555

Document type: Journal Article
Collection: School of Medicine
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