The impact of age at onset of bipolar I disorder on functioning and clinical presentation

The impact of age at onset of bipolar I disorder on functioning and clinical presentation

Biffin, Frances, Tahtalian, Steven, Filia, Kate, Fitzgerald, Paul B., De Castella, Anthony R., Filia, Sacha, Berk, Michael, Dodd, Seetal, Callaly, Pam, Berk, Lesley, Kelin, Katarina, Smith, Meg, Montgomery, William and Kulkarni, Jayashri 2009, The impact of age at onset of bipolar I disorder on functioning and clinical presentation, Acta neuropsychiatrica, vol. 21, no. 4, pp. 191-196.

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Title	The impact of age at onset of bipolar I disorder on functioning and clinical presentation
Author(s)	Biffin, Frances Tahtalian, Steven Filia, Kate Fitzgerald, Paul B. De Castella, Anthony R. Filia, Sacha Berk, Michael Dodd, Seetal Callaly, Pam Berk, Lesley Kelin, Katarina Smith, Meg Montgomery, William Kulkarni, Jayashri
Journal name	Acta neuropsychiatrica
Volume number	21
Issue number	4
Start page	191
End page	196
Publisher	Wiley Blackwell
Place of publication	Oxford, England
Publication date	2009-08
ISSN	0924-2708 1601-5215
Keyword(s)	bipolar disorder depression mania psychosis
Summary	Objectives: Recent studies have proposed the existence of three distinct subgroups of bipolar 1 disorder based on age at onset (AAO). The present study aims to investigate potential clinical and functional differences between these subgroups in an Australian sample. Methods: Participants (n = 239) were enrolled in the Bipolar Comprehensive Outcomes Study (BCOS), a 2-year longitudinal, observational, cross-sectional study. Assessment measures included the Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HAMD21), Clinical Global Impressions Scale (CGI-BP), SF-36, SLICE/Life Scale, and the EuroQol (EQ-5D). Participants were also asked about their age at the first major affective episode. Results: Three AAO groups were compared: early (AAO < 20, mean = 15.5 ± 2.72; 44.4% of the participants); intermediate (AAO 20–39, mean = 26.1 ± 4.8; 48.14% of the participants) and late (AAO > 40, mean = 50.6 ± 9.04; 7.4% of the participants). Higher rates of depression, suicidal ideation and binge drinking were reported by the early AAO group. This group also reported poorer quality of life in a number of areas. The early AAO group had a predominant depressive initial polarity and the intermediate group had a manic predominance. Conclusion: Early AAO is associated with an adverse outcome.
Language	eng
Field of Research	119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective	970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category	C1.1 Refereed article in a scholarly journal
Copyright notice	©2009, John Wiley & Sons
Persistent URL	http://hdl.handle.net/10536/DRO/DU:30035565

Document type:	Journal Article
Collection:	School of Medicine

Citation counts:	Cited 1 times in TR Web of Science Cited 1 times in Scopus
Access Statistics:	52 Abstract Views, 1 File Downloads - Detailed Statistics
Created:	Wed, 22 Jun 2011, 12:35:31 EST

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