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Combination pharmacotherapy in unipolar depression

Ng, Felicity, Dodd, Seetal and Berk, Michael 2006, Combination pharmacotherapy in unipolar depression, Expert review of neurotherapeutics, vol. 6, no. 7, pp. 1049-1060.

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Title Combination pharmacotherapy in unipolar depression
Author(s) Ng, Felicity
Dodd, Seetal
Berk, Michael
Journal name Expert review of neurotherapeutics
Volume number 6
Issue number 7
Start page 1049
End page 1060
Publisher Expert Reviews
Place of publication London, England
Publication date 2006-07
ISSN 1473-7175
1744-8360
Keyword(s) antidepressant
treatment-resistant depression
residual symptoms
major depressive disorder
combination therapy
atypical antipsychotic
Summary It is estimated that between 60 and 80% of those with major depressive disorder do not achieve full symptomatic remission from first-line antidepressant monotherapy. Residual depressive symptoms substantially impair quality of life and add to the risk of recurrence. It is now clear that depression would benefit from more vigorous treatment, in order to ameliorate its disease burden. While there are established algorithms in situations of treatment resistance, the use of combination pharmacotherapy in unipolar depression is a relatively under-investigated area of treatment and may be an effective and tolerable strategy that maximizes the available resources. This paper reviews the current evidence for combination pharmacotherapy in unipolar depression and discusses its clinical applications.
Notes Reproduced with the kind permission of the copyright owner.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, Expert Reviews
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035666

Document type: Journal Article
Collections: School of Medicine
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