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Atypical antipsychotics for bipolar disorder : overblown or blown over?

Ng, Felicity, Dodd, Seetal and Berk, Michael 2007, Atypical antipsychotics for bipolar disorder : overblown or blown over?, Clinical psychopharmacology and neuroscience, vol. 5, no. 2, pp. 53-64.

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Title Atypical antipsychotics for bipolar disorder : overblown or blown over?
Author(s) Ng, Felicity
Dodd, Seetal
Berk, Michael
Journal name Clinical psychopharmacology and neuroscience
Volume number 5
Issue number 2
Start page 53
End page 64
Publisher Korean College of Neuropsychopharmacology
Place of publication Seoul, Korea
Publication date 2007-07
ISSN 1738-1088
2093-4327
Keyword(s) bipolar disorder
clinical trials
maintenance
depression
mania
atypical antipsychotics
Summary Objective:Developments in the pharmacological treatment of bipolar disorder are of much interest, as the chronicity and disability of the disorder become better understood, and as treatment goals have shifted to emphasise early control of illness course and maintenance of euthymia in addition to acute episodic remission. Atypical antipsychotics have emerged as treatment options, and this paper aims to review the evidence for their role in bipolar disorder.

Methods:A MEDLINE search was conducted for publications up till October 2006.

Results:The search yielded a number of randomised, controlled clinical trials of various atypical antipsychotics as monotherapy or adjunctive therapy in bipolar disorder. The majority of such trials have investigated their efficacy in acute mania, with fewer studies devoted to acute bipolar depression or maintenance treatment. There are no specific trials on mixed states, which have mainly been studied together with bipolar mania. The most robust evidence supports a class effect of atypical agents in the treatment of mania.

Conclusions:
There are placebo-controlled trials that support the efficacy of olanzapine and quetiapine in bipolar depression, and of olanzapine and aripiprazole as maintenance treatment. There is strong support for the role of atypical antipsychotics in bipolar disorder management despite a relatively narrow literature base, chiefly for the treatment of mania. However, these findings need to be replicated, and further investigation is warranted to clarify their spectrum of efficacy in bipolar disorder.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, Korean College of Neuropsychopharmacology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035667

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.