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Bipolar disorder and adiposity : a study using whole body dual energy X-ray absorptiometry scans

Williams, Lana J., Pasco, Julie A., Jacka, Felice N., Henry, Margaret J., Dodd, Seetal, Nicholson, Geoffrey C., Kotowicz, Mark A. and Berk, Michael 2011, Bipolar disorder and adiposity : a study using whole body dual energy X-ray absorptiometry scans, Acta neuropsychiatrica, vol. 23, no. 5, pp. 219-223.

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Title Bipolar disorder and adiposity : a study using whole body dual energy X-ray absorptiometry scans
Author(s) Williams, Lana J.
Pasco, Julie A.
Jacka, Felice N.
Henry, Margaret J.
Dodd, Seetal
Nicholson, Geoffrey C.
Kotowicz, Mark A.
Berk, Michael
Journal name Acta neuropsychiatrica
Volume number 23
Issue number 5
Start page 219
End page 223
Publisher Wiley - Blackwell Publishing
Place of publication Malden, Mass
Publication date 2011-10
ISSN 1601-5215
0924-2708
Keyword(s) adiposity
bipolar disorder
body composition
dual energy X-ray absorptiometry scans
psychiatric epidemiology
Summary Objective: Previous research has demonstrated a relationship between adiposity and bipolar disorder, although data are derived predominantly from patient samples and use indirect methods of assessing adiposity. This study investigated the association between bipolar disorder and several indices of adiposity, including body fat mass as measured by dual energy X-ray absorptiometry (DXA), in a community-based sample.

Methods: In this study, 21 women with bipolar disorder and 523 healthy controls were drawn from an age-stratified, random, community-based sample of women (20–93 years) participating in the Geelong Osteoporosis Study. Bipolar disorder was diagnosed utilising a semi-structured clinical interview. Anthropometric measurements (weight, height, waist and hip circumference) were taken and fat mass was determined from whole body DXA scans (Lunar DPX-L).

Results: Those with bipolar disorder tended to have greater adiposity. Age-adjusted mean (95% CI) values for bipolar versus controls according to adiposity indices were weight 75.6 (68.9–82.3) versus 72.6 (71.3–74.0) kg, waist circumference 89.8 (84.1–95.6) versus 87.3 (86.1–88.5) cm, waist:hip ratio 0.85 (0.82–0.87) versus 0.84 (0.83–0.84), body mass index 27.6 (25.1–30.1) versus 27.5 (27.0–28.0) kg/m2, fat mass 31.4 (26.5–36.3) versus 28.6 (27.5–29.5) kg and %body fat 40.4 (36.9–43.9) versus 38.0 (37.3–38.7)%; all p > 0.05. Further adjustment for height, smoking, alcohol, psychotropic medication, energy intake or physical activity did not influence these patterns.

Conclusion: Although a pattern suggestive of greater adiposity among those with bipolar disorder was observed, no significant differences were detected. We cannot exclude the possibility of a type II error. Further research with a larger sample may produce more conclusive results.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Related work DU:30042980
Copyright notice ©2011, John Wiley & Sons
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035767

Document type: Journal Article
Collection: School of Medicine
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Created: Wed, 22 Jun 2011, 15:53:07 EST